packaging Flashcards
what is the purpose of packaging?
- facilitating the use of product
- convient and compliance
- identification and information
- containment during storage
- protection of tablet
- product promotion
what is primary packaging
when there is direct contact with the product
what is secondary packaging
when there is no direct contact with the product
what are the requirements for primary packaging
Must protect (sufficiently) from atmospheric factors
Must protect from biological contamination
Compliable with the product
Must offer child-resistance
Must not interact with the product
what are the requirements for secondary packaging
Provides protection against mechanical damage
Also contribute to protection from atmospheric factors
Contains info leaflet
Provides opportunity for product promotion
what are the materials which are normally used in pharmaceutical packages
- glass
- plastics
- rubber
- paper/cardboard
- metals
- laminates
what are the advantages and disadvantages of using glass as packaging
A:
-used for sterile environment
D:
not permeable to external environments - moisture and oxygen
what is the advantages and disadvantages of using plastics for packaging?
A:
-molded into the required shape - blister packs
D:
-permeability problem so water and oxygen can get in - after a long period of time
what are the advantages and disadvantages of rubbers
A:
used as stoppers
metals - A+ D
A:
do not let oxygen or moisture pass
D:
can react with the product ( aluminum tin foil ) - NeeD to be coated with resin
what determines what packaging to be used?
- required route of administration
- desired functions of the packaging
- degree of protection required - stability of API
- customer convenience
- sterility - injections or even tablets (free from pathogens)
how can you keep moisture out of products
Use of desiccant in multi-use pack- Problem: confuses users!
or
Sealed individually in controlled atmosphere
what are some package options for solid form?
Solid oral dosage forms Glass bottles Plastic bottles Blister packs Individual sachets
what is dosset cases used?
it can distribute the tablets ready to take by the patients to increase compliance
what is the disadvantages for dosset cases
Cross-contamination
Tablets are no longer sealed individually
Loss of tablet identity – exposure to atmospheric condition
Tablet integrity – tablet chipped/broken
Dose prescribed requires splitting – exposure
