powders 1

Question 1

what are the APIs physiochemical properties

Answer 1

1. chemical stability - temperature, pH
2. solubility - need to be soluble in aqueous solution to have a therapeutic effects
3. crystal forms - API exist as polymorphs but can be crystalline as well
4. hydroscopicity - the degree of moist uptake by the API

Question 2

what is a polymorph

Answer 2

many forms of crystallines

they have different chemical and mechanical properties

Question 3

what is an API

Answer 3

active pharmaceutical ingredient

Question 4

what is an excipient?

Answer 4

pharmacologically inert ingredient which gives functionality to the dosage form

Question 5

what is the factors which effect processing?

Answer 5

1. flowability - uniformity of weight
2. segregation - a little difference in particle size can cause segregation
3. bulk density - lower the bulk density - the more volume - larger the tablet which is inconvenient
   - different bulk density means different tablet weight!
4. particle size and shape - small particles - have large surface area - faster dissolution rate

Question 6

how can you improve flowability?

Answer 6

• larger particle size - make into granules ? - use a sieve
• use lube
• poor more slowly to reduce the inter particle force
• change equipment
• avoid moisture as it causes cohesion