Rectal Cancer Management Flashcards

1
Q

What is the typical surgical technique for rectal cancer?

A
  • gold standard
  • Used to be blunt dissection
  • Now sharp dissection around mesorectal fascia (fat, nodes and vessels), crm
  • Clear
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2
Q

When or why are alternative surgical techniques suggested?

A
  • Laparoscopic can be offered
  • Open surgery my be offered for locally advanced tumours
  • Robotic can be considered with appropriate audited outcomes
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3
Q

What is laparoscopic surgery?

A
  • Keyhole
  • ## MDT will discuss
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4
Q

What is Transanal Total Meso Rectal Excision?

A
  • Most people will have TME

- Remove fatty tissue containing lymph nodes, blood vessels meaning tumour is less likely to recur

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5
Q

What is an anterior resection?

A
  • Used for rectal cancers of the upper and middle part of the rectum
  • Removes part of the bowel which contains the cancer
    and rejoins the open ends
  • May result in a temporary stoma, may be reversed after a few months.
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6
Q

What is colo-anal and j-pouch surgery?

A
  • Cancer in low rectum
  • Surgeon makes a pouch from part of colon before joining to the anus
  • Pouch acts as new rectum and stores stool until it is convenient to pass them
  • May use temporary stoma
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7
Q

Abdomino - Perineal Resection is used when?

A
  • Extremely low cancer in rectum (close to anus)
  • Rectum and anus are removed
  • Long wound
  • Wound may be closed using muscle and skin from other part of body (flap)
  • Permanent stoma bag
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8
Q

What are TAE, TAMIS, TEMS?

A
  • TAE = transanal excision, enter through anus and remove tumour and small amount of tissue
  • TAMIS = laparoscopic procedure, sphincter sparing
  • TEMS = uses endoscope, sphincter sparing
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9
Q

Who is offered pre-op treatment?

A
  • Not RT for early stage (T1,T2,N0,M0) as patients are low risk
  • Will offer RT or chemo-RT if node positive
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10
Q

When is surgery offered?

A
  • T1-T2, cN1-N2, M0 or cT3-T4, any cN, M0
  • Make sure patients are aware of risk of recurrence if surgery is deferred
  • Anyone with a resectable tumour
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11
Q

What does NICE classify as high or low risk?

A
  • Margin breached or threatened, or encroaching on sphincter

- Low risk is cT1,2 or 3a

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12
Q

What is Papillon and when is it used?

A
  • Used when surgery is not suitable
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13
Q

What if a tumour is not resectable?

A
  • Pre-op RT can be used
  • Ideally will shrink tumour
  • Gap between
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14
Q

Post-op options for treatment?

A
  • Stage 3 rectal cancer, without pre-op, may be given post-op chemotherapy
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15
Q

Role of XRT in rectal cancer treatment?

A
  • Post-op with or without chemo
  • Short course pre-op
  • long course pre-op
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16
Q

Using Short Course XRT?

A
  • Moderate risk: - T3b, upper rectum, potential surgical margin threatened
  • Reduces risk of relapse
  • Improves disease free survival
  • Usually 25Gy in 5#
17
Q

Using Long Course XRT?

A
  • When margin is threatened
  • Low rectal cancers
  • T3 and T4s
  • N1 and N2
  • Tumour within 1mm of CRM
  • 42.5Gy in 20-25# over 28-35 days
  • Maybe a boost if nodal involvement
  • If inoperable - 50.4Gy in 28#
18
Q

Chemo with XRT?

A
  • Capceitabine tablets - once a day during XRT

- Alternatively Mitomycin C and 5FU IV Day 1-4 and day 29-32. 2hrs prior for day 1.

19
Q

Why concurrent chemo?

A
  • RT efficacy improved with chemo

- 5 FU is the oldest example

20
Q

What are some side effects of capceitabine?

A
  • chest pain
  • feeling sick and being sick
  • Sore mouth
  • Taste changes
  • Diarrhoea
  • Abdo pain
  • Constipation
  • Tiredness
21
Q

What happens in Papillon?

A
  • 50KeV energy brachy
  • Enema used to pretreat and local anaesthetic relaxes sphincter muscles
  • A rigid sigmoidoscopy identified tumour size and site.
  • Applicator through anus
22
Q

Who is pappillon for and what are is the prescription?

A
  • Patients who cannot have surgery (low risk)
  • T1N0 <3cm = 90Gy/3#/4 weeks
  • if T1/N1 or T2N0-1 or >3cm = followed by short course RT or chemoRT
  • T2, T3a or >3cm = RT and concurrent chemo first
  • Post-op =60Gy/2# followed by RT