Receptors

Question 1

Nicotinic Muscle (NM)

Answer 1

Type: Cholinergic Receptor
Location: Skeletal muscle (NMJ)
Function/Effect: Contraction
Signal mechanism: Ligand-gated Na+/K+ channels

Question 2

Nicotinic Neuronal (NN)

Answer 2

Type: Cholinergic Receptor
Location: Autonomic Ganglia; Adrenal Medulla; Brain
Function/Effect: Postganglionic activation; Chromaffin cells release Catecholamines into blood; Development/Learning & Memory
Signal mechanism: Ligand-gated Na+/K+ channels

Question 3

Muscarinic 1

Answer 3

Type: Cholinergic Receptor
Location: Brain; Autonomic Ganglia (Nerve Endings)
Function/Effect: High cognitive function; Stimulates Enteric NS
Signal mechanism: Gq protein linked (increase IP3, DAG, Ca++)

Question 4

Muscarinic 2

Answer 4

Type: Cholinergic Receptor
Location: Heart; Presynaptic nerve terminal
Function/Effect: Decreases HR/Decrease atrial contraction; Inhibits ACh release
Signal mechanism: Gi protein linked (Decreases cAMP)

Question 5

Muscarinic 3

Answer 5

Type: Cholinergic Receptor
Location: Exocrine glands; Pancreatic beta cells; Smooth muscle: GI, Detrusor (bladder), Eye (pupils, sphincter, ciliary), Bronchial; Endothelial cells
Function/Effect: Increase secretions (lacrimal, sweat, salivary, gastric acid); Increase Insulin secretion; Increase peristalsis, Increase bladder contraction, Myosis & Accommodation, Bronchoconstriction; NO-mediated Vasodilation
Signal mechanism: Gq protein linked (Increase IP3, DAG, Ca++)

Question 6

Alpha 1

Answer 6

Type: Adrenergic
Location: Vascular smooth muscle; Eye (pupils); Smooth muscle: Intestine, Bladder; Glands
Function/Effect: Contraction; Mydriasis; Contraction; Secretion
Signal Mechanism: Gq protein linked (increase IP3, DAG, Ca++)

Question 7

Alpha 2

Answer 7

Type: Adrenergic
Location: Presynaptic nerve terminal; Pancreatic beta cells
Function/Effect: Decreases NE release; Decreases insulin release
Signal Mechanism: Gi protein linked (Decreases cAMP)

Question 8

Beta 1

Answer 8

Type: Adrenergic
Location: Heart; Kidney; Adipocytes
Function/Effect: Increase HR/Increase contractility; Increase Renin release; Increase lipolysis
Signal Mechanism: Gs protein linked (Increase cAMP)

Question 9

Beta 2

Answer 9

Type: Adrenergic
Location: Smooth muscle: Bronchial, Myometrium (uterine); Blood vessels of skeletal muscle; Heart; Liver
Function/Effect: Bronchodilation, relaxation; Vasodilation; Increase HR; Renin release/Increase glyogenloysis
Signal Mechanism: Gs protein linked (Increase cAMP)

Question 10

Beta 3

Answer 10

Type: Adrenergic
Location: Brown adipose cells
Function/Effect: Thermogenesis, Increase lipolysis
Signal Mechanism: Gs protein linked (Increase cAMP)