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SGU FTM E2 > Drug Target Types > Flashcards

Drug Target Types Flashcards

1
Q

Ion Channels

A

Mechanism: Alter conductance
Examples: Local anesthetics - Lidocaine; Sedative-Hypnotics - Valium/Diazepam; Antiepileptics - Carbamazepine

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2
Q

G-Protein Linked Receptors

A

Mechanism: binding
Examples: B2 agonist - Albuterol (asthma); B antagonist - Propranolol (hypertension)

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3
Q

Enzyme-Linked Receptors

A

Mechanism: Receptor Tyrosine Kinase Family (cell growth & differentiation)
Examples: Insulin receptors, EGFR, Imatinib (leukemia)

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4
Q

Nuclear Receptors

A

Mechanism: Intracellular, regulate gene expression for metabolism & development
Examples: Steroid hormones - hydrocortisone cream, Thyroid hormones - Levothyroxine, Vitamin D

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5
Q

Enzymes

A

Mechanism: Inhibit enzyme activity
Examples: Aspirin, Ibuprofen, Omeprazole

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6
Q

Transporters

A

Mechanism: Neurotransmitter targets
Examples: Antidepressants - Prozac

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7
Q

Structural Proteins

A

Mechanism: Tubulin binding prevents metaphase arrest & polymerization
Examples: Anticancer drugs - Vinblastine

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8
Q

Non-Binding to molecular components

A

Antacids (neutralize gastric acid)

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SGU FTM E2 (8 decks)

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