receptor basics

Question 1

Targets for drugs?

Answer 1

enzymes, channels and transporters

Question 2

4 RECEPTOR families

Answer 2

ionotropic, metabotropic, kinase linked and nuclear

Question 3

cys loop structure and examples

Answer 3

pentameric, e.g. GABAa, nAChr and 5HT3

Question 4

ionotropic glutamate receptor structure and exmple

Answer 4

tetremer four large subunits and eg. NMDA

Question 5

P2X type strucutre and example

Answer 5

trimeric and P2XR

Question 6

GPCR structure

Answer 6

7 TM domain and 3rd loop interacts with Heterotrimeric Proteins

Question 7

different targets for Gprotiens

Answer 7

adenylyl cyclase, PLC, ion channels, RhoA

Question 8

Nucleur receptors, what ligands activate?

Answer 8

steroid hormones, ligands, vitamin A +D

Question 9

Biopharmaceuticals definition

Answer 9

Complex, high molecular weight proteins and peptides that are produced in living systems. Recombinant DNA techniques allow a specific gene that will encode for a molecule that closely resembles the human active agent to be selected.

Question 10

Biopharmaceuticals examples

Answer 10

gene therapy, oligonucleotides and engineered antibodies

Question 11

Biopharmaceuticals features

Answer 11

bigger, unique, complex mechanisms, high affinity, long half life

Question 12

3 different ways to deliver gene therapy drugs

Answer 12

liposomes - virus free and cheap, but low efficiency
DNA cassetts - virus free yet expression temporary
Retrovrus - efficient permeant but unstable and need to divide cells