Anti Inflammatory 2

Question 1

DMARDs ?

Answer 1

Disease modifying anti rheumatoid drugs

Question 2

What is methotrexate?

Answer 2

Folic acid antagonist, suppresses immune cells causing inflammation it inhibits action of t helper 1 cells

Question 3

What do T helper 1 cells normally do?

Answer 3

Activate macrophages that release cytokines which are proinflammatorybanx activated enzymes which erode bone and cartlidge

Question 4

What is sulfasalazine

Answer 4

Sulfa drug which scavanges free radicals

Question 5

What is cyclosporin and its action

Answer 5

Inhibits transcription of proinflammatory cytokines
It binds to cyclophillin in cytosol and calcium binds to calcineurin. Dephospohrylationof transcription factor= NFkappa beta

This controls transcription of cytokines

Question 6

Why do some patients of asthma not respond to bronchondilators such as salbitomol as well?

Answer 6

Polymorphism in the beta 2 receptor

Question 7

Atopic means?

Answer 7

Allergy susceptible

Question 8

Side effedts of chronic steroid use

Answer 8

Thinning of skin, muscle wastage, poor wound healing, increase abdominal fat

Question 9

New therapies to treat asthma

Answer 9

Biologicals

Inhibitors of the immune cells and mast cell signalling using humanised antibodies