antiinflammatory 1 Flashcards
NSAIDS?
non steroidal anti inflammatory drugs that act on COX to reduce Prostoglandins. Enter and block enzymatic site on COX so archanadonic acid cannot pass through
synthetic name for aspirn
acetyl salicylic acid ASA
prostoglandins role ?
mediate the constriction of smooth muscle
promote platelet aggregation
constriction of the uterus
increase the sensitivity of nociceptors
Steps to produce prostaglandins
phosphlipds in membrane - hydrolysed by phospholipase 2
produced archidonate
acted upon by cycle oxygenase
produce prostoglandins
role of prostaglandins synthase
produces different types of prostaglandins
Name different prostaglandins and role ?
PGI2 +PGE2 - hyperalgeinsic- increase nociciptor senstiivity
PGF - bronchoconstriction and bring inflammmatory cells to the area
What is COX, the different type and where they are found etc.
cyclo oxygenase enzyme
Cox 1 - in all cells, on all the time, bulkier side group causes channel in centre to be narrower
Cox 2 - in inflammatory mediating cells, have to be induced. Smaller side group of valeine so bigger channel
Cox 3 0 spliced variant of COX1 in CNS
antipyretic drugs? example?
reduce temp by acting on hypothalamus
e.g .paracetemol - it is not anti inflammatory but analgeisic and antipyeretic
NSAIDS side effects
in gut - PGs have role in maintaining mucosa layer and reducing acid so if inhibited then ulcers and gastric bleeding
Renal faliure- salt retention and high BP as COX2 role in angiotensin renin pathway
Asprin action
binds to ser residue on cox 1 so archonodonic acid cannot bind, covalent bond so permanent. Action of drug is however long it takes for body to synthesise new cox
why is action of NSAIDS different in the brain
has a reducing environment
what is Natural role of IgE
Natural” role of IgE – parasitic infections
