affinity Flashcards
1
Q
relationship between KD and affinity
A
higher the KD the lower affinity - inversely proportional
2
Q
what is KD
A
Conc of drug required to cause 50% saturation , measure in molarity
different in different tissues, used to identify a tissue
3
Q
non selecctive ligand definition
A
doesn’t show specificity between isoforms of receptors - you want a more selective drug
4
Q
what is Emax
A
efficacy
5
Q
what is efficacy
A
max response achievable from applied dosage of a drug
6
Q
When using schild to calculate affinity what do you have to ensure
A
It’s for a competitive antagonist, no information on agonist
