drug development

Question 1

steps of development from start to finish

Answer 1

target selection - enzyme, protein etc
select and find lead substance using assays
toxicology,
saftey 
mutagenecity testing
animal testing on rodents
phase 1 - healthy humans
phase 2 - ill
phase 3 - 1000+ patients
phase 4 - post release surveillance with gp data

Question 2

what is the LD50

Answer 2

see what dose kills 50% of mice. Used to determine non toxic dose

Question 3

biologicals and difference to small molecule

Answer 3

hard to predict , no max dose

have to use non human primates - risk of rejections

Question 4

what is CAR-T

Answer 4

remove T cells and reprogram with transcript you want using crispr and re inject back in

used in cancer - hodgkins lymphoma