Reading Cytology Flashcards
2 types of neutrophils
Degenerative and nondegenerative
These neutrophils are hypersegmented
Degenerative
These neutrophils have 3-5 lobes
Nondegenerative
Oval cell with odd shaped nucleus, basophillic cytoplasm, and perinuclear clear zone
Plasma cells
Large cells derived from monocytes within the tissue. Oval with lacy chromatin, blue cytoplasm with vacuoles.
Phagocytes
Macrophages
Round with round to oval nucleus that may react to fluid and change shape.
Not to be confused with malignant changes and somewhat resemble macrophages
Mesothelial cells
Round to oval with numerous blue to purple cytoplasmic granules that contain histamine and heparin
Mast cells
These 3 cells look the same as they do within blood
- Lymphocytes
- Eos
- RBCs
Cells associated with inflammation
Neutrophils and macrophages
Can be mild, moderate, or marked
inflammation
Acute inflammation that may be due to bacteria
85% neutrophils, but may also see macrophages and lymphocytes
Purulent
Can be chronic or active inflammation due to parasitic or fungal infections
50% macrophages, 75% neutrophils
Pyogranulomatous
Chronic inflammation due to parasitic or fungal infections
70% monocytes, macrophages, and giant cells, few neutrophils
Granulomatous
When inflammation decreases, so does the number of
neutrophils
Inflammation due to parasitic infections or neoplastic disorders
>10% eosinophils, may also see mast cells, plasma cells, and lymphocytes
Eosinophilic
Associated with some form of inflammation
Can be benign or malignant
Neoplastic lesions
Refers to lesion that is a condition, growth, or tumor that is not cancerous
Self-contained/localized, grows slowly and does not spread
Benign
Cancerous
Invasive and aggressive and grows quickly
Metastasizes into neighboring tissues
Malignant
Criteria of malignancy where there is variation in cell size
Anisocytosis/macrocytosis
Criteria of malignancy where there is variable size and shape of cells of the same type
Pieomorphism
Nuclear criteria of malignancy where the nucleus is larger in size
Macrokaryosis
Nuclear criteria of malignancy where there is variation in nuclear sizes
Anisokayosis
Nuclear criteria of malignancy where there are multiple nucleation in a cell
Mulinucleation
Nuclear criteria of malignancy where the chromatin is coarser than normal
Ropy or cord like
Coarse chromatin pattern
Malignant epithelial is AKA
Carcinoma
Found in clumps or clusters
Large, round in shape, with cellular variation and nuclei
High amounts of cells in the tissues
Carcinoma
Mesenchymal is AKA
Sarcoma
Small-medium in size with spindle-stellate (star) appearance
Low cellularity and does not clump
Sarcoma
Round cell tumor
Does not clump or cluster with high cellularity
Discrete round cell
Common benign tumor that occurs in adult dogs
Aspirates oily and glistening fluid
Lipoma