RCC And TCC Flashcards
What are some features of presentation of advanced RCC?
Haematuria Rarely a palpable mass Large varicocele Pulmonary embolus - tumour Loss of weight/ apetite Hypercalcaemia
Compare the epidemiology of RCC and TCC.
M:F - RCC - 3:2 TCC - 3:1
White > non-white both
RCC - 7th most common UK
TCC - 8th most common men and 14th in women
What is the initial definitive treatment of bladder TCC?
TURBT
What are 3 causes of UUT TCC?
Smoking
Phenacetin abuse
Balkans nephropathy
What is the chance of UTT TCC progressing to Bladder TCC?
40%
What are the 2 broad treatments for metastatic TCC?
What are the difference between these 2 in terms of renal function?
Systemic chemo (cis-platin based)
Immunotherapy - ABs target programmed cell death receptor 1
(Atezolizumab, Pembrolizmubab)
Immunotherapy can be given in the presence of poor renal function
Give clinical features of advanced TCC.
Cachexia/ apetitie loss
DVT
Lymphodema
Renal colic (clot passing)
Give 5 risk factors for RCC.
Male White Smoking Obesit Dialysis
Give 4 risk factors for upper urinary TCC
Smoking
Phenacetin abuse
Balkans nephropathy
Previous bladder TCC (5% chance of becoming UT TCC)
What procedures can be done in treatment of localised RCC?
Palliative?
Radical nephrectomy/ partial nephrectomy
Ablation (cryo or radiofreqeuncy)
Sunitinib sorafenib pazopenib
What is a chemotherapeutic agent that can be given in bladder TCC?
Mitomycin C (single intravesicle instillation of mitomycin C)
What is T4a in terms of bladder cancer staging?
Through epithelium, CT, muscle and perivesicle fat into the prostate
Which stages of bladder cancer are superficial?
Ta T1
Which stages of bladder TCC are muscle invasive?
T2 T3 and T4
What is the most likely presentation of a Wilms tumour?
Asymptomatic abdominal mass in child
Can have haematuria, hypertension varicocele but less common
