Glomerular Patholgu Flashcards
Name 3 secondary causes of nephrotic syndrome.
Diabetic nephropathy
Amyloidosis
SLE
What are the four compartments the cortex can be split into?
Glomerular
Tubular
Vascular
Interstitial
Which primary cause of nephrotic syndrome may occur secondary to lymphoma?
Membranous GN
What Ig is depositied in membranous GN?
IgG
What is the most common cause for GN?
IgA nephropathy
What is the triad seen in nephritic syndrome?
Haematuria
Reduction in GFR
Hypertension
Outline management for nephrotic syndrome.,
Oedema
ACI
Manage hypercholestolaemia
Steroids if MCD (treat underlying)
What are some systemic symptoms associated with ANCA vasculitis?
ANCA vasculitis is pauci-immune. True or false?
Arthlargia
Myalgia
Weight loss
Fatigue
True
What does Anti-GBM almost always cause?
Men or women more likely?
RPGN
Men
What type of sensitivity reaction is lupus?
Type III
What are the clinical findings that can be seen with progressive diabetic nephropathy.
Initial hyperfiltration - increased GFR
Latent Stage - Mesangial expansion and GBM thickening
Microalbuminuria (normal to slight high GFR)
Overt proteinuria
ESRD
Give risk factors for diabetic nephropathy.
Genetic susceptibility Hyperglycaemia hypertension High level of hyperfiltration Increasing age Durationof diabtes Smoking
What’s are the 3 main histopathological changes seen in diabetic nephropathy?
Diffuse nodular Glomerular sclerosis (kimmelsteil-Wilson nodules)
Thickening of GBM
Mesangial expansion
