Control Of Volume Flashcards
What two transporters are inhibited through pressure natriuresis?
Na H antiporter and Na K ATPase (basolateral)
Both in the PCT
What AQP channels are found in the PCt and dL?
What AQP channels are found in CD?
1 and 7
234
Name 2 regions of the nephron where NKCC2 is found
Thick ascending limb
Macula densa
What is the difference in Na reabsorption in early and late DCT?
Early DCT - symport with Cl
Late - ENaC
What 3 things have preferential reabsorption in the PCT?
Glucose AA and lactate
How is a glucose reabsorbed in the S1 segment of the PCT?
SGLT2 then GLUT(2) basolateral
Symported with 3 Na
How is Na reabsorbed in S2-S3 segments of the PCt?
NaH exchanger
How does transcellular/ paracellular reabsorption of Cl occur in late PCT?
Cl-formate exchanger apical
K Cl symport basolateral
Diffusion through tight junctions
Name 3 driving forces for absorption of solute from the interstitial into capillaries.
Increased osmotic pressure in the interstitium
increased hydrostatic pressure due to isosmotic reabsorption
Increased oncotic pressure in the peritubular capillaries
How is Cl reabsorption carried out in the TAL?
NKCC2 Apical
Cl K symporter
CLC-NKB Cl channels
How does chloride reabsoprtion in the early DCT work?
NCC apical
ClC-KB channels and KCC4
How does K plus pumped into the cell from interstitium by Na K ATPase in the early DCT leaves the cell how?
Kir (inward rectifier) channels
Describe Ca reabsorption occurs in the DCT.
TVRP5 apical
NCX and Ca ATPase basolateral
What is the difference in roles of A and B intercalated cells in the collecting duct?
AIC - secretion of H+
BIC - secretion of HCO3-
