RBC and Bleeding Disorders Flashcards
Most common nutritional disorder in the world
IDA
Most common cause of anemia in hospitalized patients
Anemia of chronic disease
Specific viral cause of pure red cell aplasia
Parvovirus B19
RBC profile of aplastic anemia and pure red cell aplasia
Normocytic, normochromic
SOL replaces normal marrow elements, most commonly metastatic cancer
Myelopthisic anemia (with dacrocytes)
Eponym for anemia of beta thalassemia major
Cooley’s anemia (HbF)
Two broad categories of platelet number disorders
ITP and thrombotic microangiopathies (TTP and HUS)
Main pathology in PNH
PIGA mutations leading to deficiency of complement regulatory proteins (CD55, CD59 - most important, inhibits C3 convertase to prevent complement activation, C8 binding protein)
Agent used in PNH that prevents activation of C5 to C5a
Eculizumab
Difference between TTP and HUS
TTP has fever and neuro involvement (while both have microangiopathic hemolytic anemia, thrombocytopenia, and renal failure)
Typical HUS is caused by this organism
E. coli O157:H7 (with Shiga-like toxin)
Disorder of platelet adhesion with thromboytopenia, involving GP1b-IX deficiency
Bernard-Soulier
Disorder of platelet aggregation without thrombocytopenia involving GPIIb-IIIa deficiency
Glanzmann thrombasthenia
Most common inherited bleeding disorder
Von Willebrand disease
Most common life-threatening inherited bleeding disorder
Hemophilia
