Rapid Review Cardiovascular Flashcards
fClassic EKG finding in atrial flutter
Sawtooth P waves
Definition of unstable angina
Angina that is new, worsening, occurs at rest
Antihypertensive for diabetic pt w/ proteinuria
ACEI
Becks triad for cardiac tamponade
Hypotension
Distant heart sounds
JVD
Drugs that slow HR
Beta blockers
CCB
Digoxin
Amiodarine
Hypercholesterolemia Tx that leads to flushing and pruritis
Niacin
Mumur of HOCM
Systolic ejection murmur along lateral sternal border that increases with decreased preload (i.e. Valsalva)
Murmur of aortic insufficiency
Austin flint murmur:
Diastolic, descrescendo, low pitched, blwing murmur best heard sitting up
Increases with increased afterload (i.e. handgrip)
Murmur of AS
3 cases when valve replacement needed
Systolic crescendo-descrescendo radiates to neck
Increases with increased preload
Replace: ACS- angina, CHF, syncope
Murmur of MR
Holosystolic mumur that radiates to axilla or carotids
Increases with increased afterload (handgrip)
Mumur of MS
Diastolic mid to late low pitched mumur preceded by opening snap
Tx for aflutter and afib
Unstable - cardiovert
Stable or chronic- rate control with CCB or Beta blocker
Tx vfib
Immediate cardioversion
Dressler’s syndrome
AI reaction
Fever, pericarditis, increased ESR 2-4 weeks post MI
IVDU with JVD and holosystolic murmur at left sternal border….Tx
Treat existing HF and replace tricuspid valve
Diagnostic test for HCM
Echo (shows thickened LV wall and outflow obstruction)
Pulsus paradoxus
Decrease in SBP >10 mmHg with inspiration
Seen in cardiac tamponade
Classic EKG in pericarditis
Low voltage, diffuse ST segement elevation, PR depression
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Definition of HTN
BP >140/90 on 3 separate occassions 2 weeks apart
Eight surgically correctable causes of HTN
- Renal a stenosis
- Coarctation of the aorta
- Pheochromocytoma
- Conn’s syndrome
- Cushing syndrome
- Unlateral renal parenchymal disease
- Hyperthyroidism
- Hyperparathyroidism
Evaluation of pulsatile abdominal mass and bruit
ABD US and CT
Indications of surgical repair of AAA
>5.5 c, rapidly enlarging, symptomatic, ruptured
Tx ACS
MONA: morphine, ASA, sublingual nitrogen, O2 +heparin, clopidogrel, IV beta blockers
Metabolic syndrome
- Abdominal obesity
- High TG
- Low HDL
- HTN
- IR
- Prothrombotic or proinflammatory states
Dx test for 50 y.o. man with stable angina that can exercise to 85% of max HR
Exercise stress treadmill with ECG
Dx test for 65 y.o. woman with LBBB and severe OA with unstable angina
Pharmacologic stress test (dobutamine echo)
Target LDL in pt w/ DM
<70
Signs of active ischemia during stress test
- Angina
- ST segment changes on EKG
- Drop in BP
EKG findings suggesting MI
ST segment leevation (depression means ischemia), flattened T waves, Q waves
Anterior wall is suppled by which aa
LAD
Diagonal
Inferior wall is supplied by which aa
PDA
Posterior wall is supplied by which aa
LCA/oblique
RCA/marginal
Interventricular septum supplied by which aa
LAD/diagonal
Young pt with angina at rest and ST segment elevation with normal cardiac enzymes
Prinzmetal’s angina
Common Sx associated with silent MI
CHF
Shock
Altered mental status
Dx test for PE
Spiral CT with contrast
Protamine reverses
Heparin
PT
Coagulation parameter effected by warfarin
Coagulation factors I, II, V, VII, X = EXTRINSIC
PTT
Monitor heparin
Factors: I, II, V, VIII, IX, X, XI, & XII- INTRINSIC and COMMON
Does not measure: VII and XIII
Youn pt with FH of sudden death collapses and dies while exercising
HCM
Endocarditis prophylaxis regimens
Oral surgery: amoxicillin
GI or GU: not recommended
Virchow’s triad
- Stasis
- Hypercoagulability
- Endothelial damage
Most common cause HTN in women
OCP
Figure 3 sign
Aortic coarctation
Water bottle shaped heart
Pericardial effision
Look for pulsus paradoxus
Kussmaul’s sign, causes?
Increase in JVP with inspiration
RV infarction, postop cardiac tamponade, constrictive pericarditis, TR
Murmur of MVP
Midsystolic or late systolic mumur with preceeding click
Murmur of AR
Acute causes?
History of pt in acute AR?
Early diastolic descrendo mumur, at left sternal border (Austin Flint murmur)
Acute causes: infective endocarditis, aortic dissection, trauma
Hx: rapid onset pulm congestion, cardiogenic shock, severe dyspnea
Murmur of MS
Diastolic mid to late low pitched murmur
S3 gallop - when and why
Due to high output states- normal in young kids, and pts
Dilated CMP (floppy ventricle), MV disease
S4 gallop
Normal in young and athletes
HTN, diastolic dysfcn (stiff ventricle), AS
Pulsus alternans
Alternating weak and strong pulses
Cardiac tampnade, asthma, COPD, tension pneumo, FB in airway
Pulsus parvus et tardus
Weak and delayed pulse
AS
When would peripheral pulses be increased?
Compensated AR, coarctation (UE>LE), PDA
Used to increase HR in bradycardia
Atropine
Causes afib
PIRATES = ACUTE
Pulmonary disease
Ischemia
Rheumatic heart disease
Anemia/Atrial myxoma
Thyrotoxicosis
Ethanol
Sepsis
CHRONIC- HTN, CHF
Tx acute CHF
LMNOP
Lasix
Morphine
Nitrates
Oxygen
Position (upright)
Causes dilated CMP
Most common 2nd: HTN and ischemia
Idiopathic
Alcohol
Myocarditis
Postpartum
Drugs (doxorubicin, AZT, cocaine)
Endocrinopathies (thyroid, acromegaly, pheo)
Infection (coxsackie, HIV, Chagas, parasites)
Genetics
Nutritional (wet beriberi)
Prinzmetal’s angina
Mimics angina pectoris
Due to vasospasm of coronary vessels
Young women, at rest, early morning
ST elevation w/o cardiac enzyme elevation
Sequence of EKG changes in MI
Peak T waves
ST segmenet elevation
Q waes
T wave inversion
ST segment normalization
T wave normalization
St segment elevation in II, III, aVF - MI? Vessels?
Inferior MI
RCA/PDA and LCA
ST segment elevation in V1-V4 - MI? Vessels?
Anterior MI
LAD and diagonal
ST segment elevation I, aVL, V5-V6 MI? Vessels?
Lateral MI
LCA
ST segment depression V1-V2
Acute transmural infarct in posterior wall
CABG indications
Unable to perform PCI 2/2 diffuse disease
Left main coronary artery disease
Triple vessel disease
Depressed ventricular function
Complicatons of post MI
- First day
- 2-4 days
- 5-10 days
- weeks to months
- heart failure
- arrhythmia, pericarditis
- LV wall rupture (pericardial tamponade causing electrical alternans and pulseless electrical activity), papillary mm rupture (severe MR)
- Ventricular aneurysm (CHF, arrhythmia, persistent ST elevation, MR, thrombus)
Rx for HTN
ABCD
ACEI/ARB
Beta blocker
CCB
Diuretics- #1
Causes 2nd HTN
CHAPS
Cushing syndrome
Hyperaldosteronism
Aortic coarctation
Pheo
Stenosis of renal aa
Triad of Conn’s syndrome
Labs?
- Unexplained hypokalemia
- Metabolic alkalosis
- HTN
Labs: increased aldo and decreased renin
Causes Cushing’s syndrome
Cuase: ACTH producing pituitary tumor or ectopic tumor, cortisol secrtion by adrenal adenoma or carcinoma, exogenous steroids
Causes pericarditis
CARDIAC RIND
Collagen vascular disease
Aortic dissection
Radiation
Drugs
Infections
ARF
Cardiac (MI)
Rheumatic fever
Injury
Neoplasms
Dressler’s
Most common risk factor aortic aneurysm vs aortic dissection
Aneurysm: atherosclerosis
Dissection: HTN
Most common location aortic dissection
Above aortic valve or distal to L subclavian
Gold standard Dx aortic dissection
CTA
Stanford system of classification of aortic dissection
A: proximal or ascending (ascending is surgical emergency)
B: descending- medically manage
6 Ps of acute ischemia
Pain
Pallor
Paralysis
Pulse deficit
Paresthesias
Poikilothermia
ABI where pain occurs at rest in PVD
<0.4
Hemophilia A
Which test prolonged: PT, PTT, BT?
Low levels of which factor?
Inheritance
PTT
Low Factor VIII
X-linked
Hemophilia B
Which test prolonged: PT, PTT, BT?
Low levels of which factor?
Inheritance?
PTT
Low factor IX
X linked
vWF deficiency
Which test prolonged: PT, PTT, BT?
Low levels of which factor?
Inheritance?
BT and PTT
Normal or low factor VIII
AD
DIC
Which test prolonged: PT, PTT, BT?
Peripheral Smear?
Causes
PT, PTT, BT; + D-dimer or FDP
Schistocytes
Infection, postpartum, malignancy
Liver Disease
Which test prolonged: PT, PTT, BT?
Low levels of which factor?
PT
All low but factor VIII
Vit K def
Which test prolonged: PT, PTT, BT?
Low levels of which factor?
Cause?
PT, PTT (slight)
Factors II, VII, IX, X, Protein C and S
Neonate, malabsorption, alcoholic, prolonged abx use which kills Vit K making bacteria
Uremia affects which component of blood?
PT, PTT, BT increased?
Tx?
Platelet
BT
Desmopresssin
Cor pulmonale
Tx
RV enlargement, hypertrophy, or failure due to primary lung disease (can be caused by sleep apnea)
Tx: pulmonary vasodilators -prostacyclins, antiendothelins, PDE5 inhibitors, CCB
Differential Dx Chest Pain
CHEST PAIN
Cocaine/Costochondritis
Hyperventilation/HSV
Esophagitis/Esophageal spasm
Stenosis of aorta
Trauma
PE/Pnuemo/Pericarditis/Pancreatitis
Angina/Aortic Dissection/ Aortic aneurysm
Infarction (MI)
Neuropsych Disease (depression)
Tx VTach
Amiodarone
When is the greatest risk of sudden death following an MI?
What are the 3 major causes?
First few hours
Vtach, Vfib, cardiogenic shock
Class IA antiarrhythmic
Drugs?
Use?
Channels?
Quinidine, proacinamide
PSVT, Afib, Aflutter, Vtach
Na+- AP prolonged
Class IB antiarrhythmic
Drugs?
Use?
Channels?
Lidocaine, tocainide
Vtach
Na+ blockers- shorten AP
Class IC antiarrhythmic
Drugs?
Use?
Channels?
Flecainide, propafenone
PSVT, Afib, Aflutter, PSVT
Na nlockers - no change AP
Class II antiarrhythmic
Drugs?
Use?
Beta blockers - propranolol, esmolol, metoprolol
PVC, PSVT, Afib, Aflutter, Vtach
Class III antiarrhythmic
Drugs?
Use?
Channels
Amiodarone, Sotalol, Bretylium
Afib, Aflutter, Vtach (no breytlium)
K blockers
Class IV antiarrhythmic
Drugs?
Use?
Channels
Verapamil, Diltiazem
PSVT, Afib, Aflutter, MAT
Ca blockers
Functions of Angiotensin II
Vasoconstriction (arterial smooth mm)
Increase Aldo (at adrenal gland - increase Na reabsorption in kidney)
Increase NE release (SNS)
Stimulate thirst and vasopressin (brain)
Increase contractility and ventricular hypertrophy of heart
Valsalva effect on AS and HOCM
AS: decrease murmur
HOCM: increase murmur
Specific gravity and causes of transudate vs exudate of pericardial effusion
Exudate >1.020- high in protein; think neoplasm, fibrotic disease, TB
Transudate <1.020 - low in protein
Causes myocarditis
Drugs: doxorubicin, chloroquine, penicillins, sulfonamides, cocaine, radiation
Infection
- Virus: coxsackie, parvovirus B-19, HHV-6, adenovirus, echovirus, EBV< CMV, influenza
- Bacteria
- Rickettsia
- Fungi
- Parasites
Cause myocarditis in S America, common assocaition
Chagas- Trypanosoma crzui
Achalasia
H/P GAS infection- acute rheumatic fever
Migratory arthritis, hot swollen joints, fever, sub1 nodules on extensor surface, Sydenham chorea, erythema marginatum (painless)
JONES criteria for Rheumatic Heart Disease
Jones Peace
Major:
Joints (polyarticular, hot and swollen)
Heart: carditis
Nodules
Erythema marginatum
Sydenham Chorea
Minor:
Previous rheumatic fever
ECG with prolonged PR
Arthralgias
CRP and ESR elevated
Elevated T
Need 2 major or 2 minor and 1 major
Bugs that would result in negative culture endocarditis
HACEK
Haemophilus
Actinobacillus
Cadiobacterium
Eikenella
Kingella
Bugs common on prosthetic valve
Staph epidermidis
Staph aureus
Acute vs subacute bugs that cause endocarditis
Acute: Staph aureus, Strep pyogenes/pneumo, Neisseria gonorrhoeae
Subacute: strep viridians, Enterococcus, fungi, Staph epi
Tx bacterial endocarditis
4-6 weeks IV abx
Beta lactam + aminoglycoside
penicillin, cephalosporins, monobactams, and carbapenems
amikacin, arbekacin, gentamicin, kanamycin, neomycin, netilmicin, paromomycin, rhodostreptomycin,[2] streptomycin, tobramycin, and apramycin
DM
Best antiHTN Rx?
Worst?
Best: ACEI for kidneys
Worst: Thiazide (impair glc tolerance) and beta blocker (mask hypoglycemia)
CHF
Best antiHTN Rx?
Worst?
Best: ACEI/ARB; Aldo antag; Beta blockers
Worst: CCB - reduce rate/contractility- make HF worse
Post MI
Best antiHTN Rx?
Worst?
Best: Beta blocker, ACE/ARB, Aldo antag
Worst???
BPH
Best antiHTN Rx?
Worst?
Best: selecative alpha 1 blocker
Worst:??
Migraine
Best antiHTN Rx?
Worst?
Best: Beta blocker
Worst: ??
Osteoporosis
Best antiHTN Rx?
Worst?
Best: thiazide- maintain normal/high serum Ca
Asthma/COPD
BEst???
Worst: Nonselective Beta blocker- bronchoconstriction
Pregnancy
Best antiHTN Rx?
Worst?
Best: Hydralazine, methyldopa, labetaolol. nifedipine
Worst: thiazide ( increased bv during pregancy should be maintained), ACE and ARB are teratogens
Gout
Best antiHTN Rx?
Worst?
Best??
Worst: Diuretic - increase uric acid in serum
Depression
Best antiHTN Rx?
Worst?
Best???
Worst: beta blockers - worsen Sx
BP of HTN urgency/ emergency
Emergency vs urgency
> or = 180/120
Emergency: evidence of end organ damage - progressive renal failure, pulm edema, aortic dissection, encephalopathy, papilledema
Tx HTN emergency
Reduce DP to 100 using IV nitroprusside, labetolol, nicardipine, fenoldopam
Then use Beta blocker or ACEI orally to reduce BP
Use diuretics for pulm edema
Meds used in PVD to help slow occlusion (2)
Pentoxifylline
Cilostazol
Nitroprusside dilates?
AA and VV
Nitroglycerin dilates
VV
Hydralazine dilates
AA
Alpha 1 antagonist dilates
AA
CCB dilates
AA
Secondary causes HLD
Uncontrolled DM
Hypothyroidism
Nephrotic syndrome
Obstructibe liver diseae
Excessive EtOH (raise TG)
Obesity
Meds (OCP, isotretinoin, glucocorticoids, thiazides, beta blockers)