Psych Flashcards
First line Rx for depression
SSRI
Antidepressants associated with HTN crisis
MAOI
Galactorrhea, impotence, menstrual dysfunction, and dec libido
DA antagonist
17 yo female left arm paralysis after boyfriend dies in car crash. No medical reason
Conversion disorder
Defense mechanism: Mother who is angry at her husband yells at her child
Displacemtn
Defense mechanism: Pedophile enters monastery
Reaction formation
Woman calmly describes grisly murder
Isolation
Hospitalized 10 yo begins to wet his bed
Regression
Life threatening mm rigidity, high fever, rhabdo
NMS - neuroleptic malignant syndrome
Amenorrhea, low body weight (<85%), bradycardia, abnormal body image in young woman
Anorexia
35 yo man recurrent episodes of palpitations, diaphoresis, fear of going crazy
Panic disorder
Most serious side effect of clozapine
Agranulocytosis
21 yo man has 3 months of social withdrawal, worsening grades, flattened affect, concrete thinking
Schizophreniform disorder (schizophrenia needs >6 mo)
Key side effect atypical
Weight gain, DM II, QT prolongation
Young weight lifter receives IV haloperidol and complains eyes are deviated sideways, Dx. Tx
Acute dystonia (oculogyric crisis) Tx benztropine or diphenhydramine
MEds to avoid in pts with hx alcohol withdrawal seizures
NEuroleptics
13 yo boy has hx of theft, vandalsim, violence toward family pets
Conduct disorder–assoc with antisocial personality disorder
5 mo old girl dec head growth, truncal discoordination, dec social interaction
Rett’s disorder–loss of milestones is commonly described
Pt hasnt slept for days, lost $20,000 gambling, agitated, pressured speech. Dx? Tx
Acute mania. Start with mood stabilizer - Li
After minor fender bender, man wears neck brace and requests permanent disability
Malingering
Nurse presents with severe hypoglycemia. blood analysis reveals no elevation C peptide
Factitious disorder (Munchausen)
Pt continues to use cocaine ager being in jail. losing job, not paying child support
Substance abusse
Meds to avoid in pts with PTSD
Benzodiazepines - high addiction potential
Violent pt w/ vertical and horizontal nystagmus
PCP
Woman was abused as child frequently feels outside of or detached from her body
Depersonalization disorder
Schizophernic pt takes haloperidol for 1 yr and develops uncontrollable tongue movements. Dx Tx
Tardive dyskinesia
Dec or discontinue haloperidol and try another antipsych (risperdone, cloazpine)
Man with major depressive disorder counseled to avoid tyramine rich food with new med
MAOI
DSM IV - category I
Clinical psych disorders - mood, anxiety, substance, delirium
DSM IV- category II
PD and developmental disorders - BPD and mental retardation
DSM IV - category III
MEdical conditions - encephalopthy, neoplasm, HIV
DSM IV - psychosocial stresses
Support structures, social environment, occupational factors
DSM V - global assessment of functioning
100 pt scale that describes how well pt has functioned in society
Mood vs affect
Mood - subjective
Affect - way person expresses his or her state of mind
Insight vs judgment
Insight: pts awareness of problems and their affect on daily life (pre contemplation–>contemplation–>action–>maintenance)
Judgment - response to a situation
Awareness of time, place, identity
Orientation
Ability to retrieve mentally stored information
Memory
Ability to maintain attention to task
Concentration
Major Depressive Disorder
Which characteristics essential for Dx?
SIG E CAPS Sleep disturbance - insomnia Interest loss Guilt Energy reduction - fatigue Concentration impairment Appetite changes Psychomotor disturbances Suicidal ideation NEED 5
Either Depressed mood or anhedonia
Time frame to Dx MDD
> 2 weeks
NT involved in depression
5HT, NE, DA
Risks for successful suicide attempt
age>45 violent behavior drug use prior attempt plan male recent loss depression unemployed widowed, single, divorced
Bereavement - time line, major criteria
6 months
DO NOT AFFECT ABILITY TO FUNCTION
Depression after loss of loved one
Time line
S/S
> 6 months
Detachment, bitterness, inability to accept life without the deceased, agitation, distrust
Dysthymic disorder
Define
Time line
> 2 yrs - depressed on more days than not, no hx MDD -Hopelessness -Change sleep -Change appetite -Fatigue -Inability to concentrate -Low self esteem NEED 2 w/ depressed mood
Bipolar I vs II
I: depression with 1+ manic
II: depression with 1+ hypomanic
Mania vs hypomania
Mania: > 1 wk-->DIG FAST; affects ability to function -Distractibility -Insomnia -Grandiosity -Flight of idea -Activity -Speech pressured -Taking risks NEED 3
Hypomania 4 or more days - does not impair ability to fcn
Tx bipolar
Mood stabilizers - lithium, lamotrigine, atopyicals
Lithium first line mania
SSRI
Mechanism
Use
SE
Block 5HT reuptake
First line: depression; also for anxiety and PTSD
Sexual dysfcn, increase SI in adolescents
fluoxetine, sertaline, paroxetinee citolapram, escitolopram
SNRI
Mechanism
Use
SE
Inhibits 5HT and NE reuptake
1st line depression with comorbid neuro pain
2nd line if fail SSRI
HTN, insomnia/sedation, nausea, constipation, dizziness
Venlafazine, Duloxetine
TCA
Mechanism
Use
SE
Block NE and 5HT reuptake - like SNRI; also hit alpha and muscarinic
2nd line depression used if comorbid neuro pain
Easy to OD, fatal 5x therapeutic dose; QT prolong, sedate, weight gain, sexual, antichol Sx
Imipramine, amitryptiline, desipramine, nortiptyline
MAOI
Mechanism
Use
SE
Block MAO to inhibit deamination of 5HT, NE, and DA
2nd line depression; used Tx depression with neuro Sx or refractory
Dizziness, tyramine = HTN crisis, dry mouth,
Phenelzine, Isocarboxazid, tranylcypromine, selegiline
Buproprion
Mechanism
Use
SE
DA and NE
Depression with fatigue and concentration problems; smoking
NO SEXUAL DYSFCNl weight loss, HA
Trazodone
5ht
Depression with insomnia
Sedation, priapism, seizure high dose, hypotension
Mitrazapine
alpha 2 and 5HT blockade
Depression with insomnia
Dry mouth, weight gain, sedation
St Johns Wort
Mechanism
Use
SE
Decrease reuptake 5HT, NE, DA
First line in Europe, alternative in us
MANY DRUG INTERACTIONS
Rapid cycling hypomania with mild depression > 2 yrs without period of normal mood > 2months
Cyclothymia - Tx mood stabilizer
How to precipitate mania in bipolar disorder
Taking antidepressants without mood stabilizer
Behavioral or mood changes within 3 months of stressful event and impait ability to finction
Time frame of beginning and ending
Tx
Adjustment disorder with depressed mood
begin within 3 months of event and end 6 months after end of sterssor
Tx: psychTx, antidepressants
Organic disorder associated with panic disorder
MCP
Agorophobia also
Dx of panic attacks requires
Hx of recurrent episodes plus persistent fear that will happen again
Tx panic attacks
PsychTx, SSRI, SNRI
TCA 2nd line
Tx specific phobia
PsychTx to desensitize
Tx social phobia
PsychoTx Beta blockers SSRI MAOI if refractory BDZ for anxiety
Major necessity for OCD Dx
Impairs daily life
Pt recognizes sx and wants to get rid of them
Tx OCD
PsychoTx
SSRI or clomipramine
Vivid dreams or recurrent intrusive thoughts, detachment, avoidance, guilt
PTSD
Dx requires exposed to traumati event, Sx of reliving event (dreams or thoughts), increased arousal (insomnia, irritable, difficulty concentrationg)
Dx PTSD requires
Dx requires exposed to traumatic event, Sx of reliving event (dreams or thoughts), increased arousal (insomnia, irritable, difficulty concentrationg) lasting > 1month if acut e>3 months if chronic
Tx PTSD
SSRI
MAOI
Mood stabilizer
PsychoTx
Time line generalized anxiety disorder
> 6 months
Dx of GAD requires
Excessive anxiety for most days
Impairment of ability to fcn
> 6 months
GAD Tx
PsychoTx
Anxiolytics (BDZ, Buspirone)
SSRI and SNRI promising prospect
How much BDZ need to OD
Tx OD
> 1000x dose
FLumazenil
BDZ
Mechanism
Indications
SE
Increase GABA inhibition of neural firing
Alprazolam- rapid onset and short half life = break panic attacks
Clonazepam and diazepam - prolonged
SE: sedation, confusion; withdrawal (alprazolam)
Buspirone
Mechanism
Indications
SE
DA and 5HT
Anxiety in which abuse or sedation is a concern
HA, dizzy, N
Schizophrenia puts pt at risk for
Substance abuse
Suicide
Risk factor shcizophrenia
FH, maternal malnutrition or illness, homeless and indigent
Positive Sx schizophrenia
Delusion Hallucination Disorganized thought and behavior thought broadcasting ideas of reference