Obstetrics Flashcards
primary cause third trimester bleeding
Placental abruption and placenta previa
Classic US and gross appearance of complete hydatidiform mole
Snowstorm on US
Cluster of grapes on gross exam
Chromosomal pattern of complete mole
46 XX
Molar pregnancy containing fetal tissue
Partial mole
Sx of placental abruption
Continuous painful bleeding
Sx of placenta previa
Self limited, painless vaginal bleeding
When should a vaginal exam be performed with suspected placenta pre via?
Never
Abx with teratogenic effect
Tetracycline
Fluoroquinolones
Aminglycosides
Sulfonamides
Most common cause of postpartum hemorrhage
Uterine atony
Tx postpartum hemorrhage
Uterine massage
If that fails - oxytocin
Abx prophy for GBS
IV penicillin or ampicillin
Meds to accelerate fetal lung maturity
Bethamethasone or dexamethasone x 48 hrs
Pt fails to lactate after an emergency C section with marked blood loss
Sheehan syndrome (postpartum pituitary necrosis)
Uterine bleeding at 18 weeks gestation, no products expelled, cervix open
Inevitable abortion
Uterine bleeding at 18 wks gestation, no products expelled, cervical os closed
Threatened abortion
Teratogens effect during which weeks
2-12 wks
Which is older, gestational age or embryonic/developmental age? by how much
Gestational age 2 weeks older than embryonic age because is based on LMP which is 14 d prior to fertilization which occurs at ovulation
Naegele rule
EDP = LMP + 7 days - 3 months + 1 year
CV changes in pregnancy
CO increased 40% with SV and HR increase Systolic murmur b/c inc CO Myocardial O2 demand increases SP and DP decrease Uterus push heart superiorly Venous distension increases PVR decreases
Respiratory changes in pregnancy
Uterus pushes diaphragm up and decreases RV, FRC, ERV
Total O2 consumption increases
TV increases 40% with increase in minute ventilation 2/2 progesterone stimulation
PCO2 decreases = dyspnea
VC does not change
Renal changes in pregnancy
Renal plasma flow and GFR increase
BUN and Cr decrease
Inc renal loss bicarb due to compensation for resp alkalosis
Blood and interstitial fluid v increases
Endocrine change in pregnancy
Nondiabetic hyperinsulinemia with mild glc intolerance
Production human placental lactogen inc glc intolerance by interfering with insulin activity
Fasting TG inc
Cortisol Inc
TBG and T4 inc, free T4 unchange
TSH decrease but WNL
Hematologic changes in pregnancy
Hypercoaguable state
Increased RBC
HCT dec bc inc blood V
GI changes in pregnancy
Inc salivation
Dec gastric motility
Increased gastric emptying time
Sphincter tone decreases
Weight gain mom
Calorie intake
BMI 26: 15-25 lbs
Calories: 2500
Labs at initial visit
9-14 wks CBC Blood ab and Rh Pap GC/Chlam UA-every visit RPR or VDRL Rubella titer Hep B surface antien HIV TSH?
Labs 16-18 wks
Quadruple screen - trisomies 21, 18, NTD
Labs 18-20 wks
US dating and anatomy
Labs 24-28 wks
1 hr OGTT
labs 32-37 wks
N\GC and chlam, HIV and RPR screen in high risk
GBS screening
4 things tested in Quadruple screen
AFP- maternal serum
Estriol
hCG
maternal serum inhibin A
Tested in full integrated test
US for nuchal translucency and serum for pregnancy associated plasma protein A - first trimester
Quadruple screen - 2nd semester
Amniocentesis tests
Who gets tested?
Amniotic fluid after 16 wks for AFP and karyotype
Tested:
- Abnormal quadruple
- Rh sensitized mom to obtain fetal blood type
- Evaluate fetal lung maturity via L:S >=2.5 or detect PG
- > 35 yrs
Chorionic villous sampling tests
9-12 wks gestation for chromosome abnormalities
Percutaneous umbilical cord sampling tests
> 18 wks: chromosome defect, fetal infection, Rh sensitization
Maternal serum AFP
- When valid
- If high this means?
- If low this means
Valid only 16-18 wks
High levels: NTD (ancephaly or spina bifida) or multiple gestation, abdominal wall defect (gastroschisis, omphalocele), incorrect dating, fetal death, placental abnormalities (placental abruption)
Low levels: trisomies 21 and 18, fetal demise, inaccurate dating
AFP low, hCG high, Inhibin A high, estriol low (Quad)
Nuchal translucency high, hCG high, PAPP-A high (full integrated)
Trisomy 21
AFP low, estriol low, hCG low, Inhibin A WNL/low - quad
Nuchal translucency high , hCG and PAPP-A low - full integrated
Trisomy 18
Quad screen WNL
Nuchal translucency inc, hCG dec, PAPPA, dec
Trisomy 13
AFP levels
- when are they valid
- if low/high
- Valid wks 16-18
- High: NTD or multiples
- Low: trisomyy 18 or 21
1 hr OGTT
- Oral glc load
- Abnormal
- 50 g
- >=130
3 hr OGTT
- test setup
- abnormal
3 days carb meals, fasting glc measured , 100 g load, measure glc 1,2,3 hrs
Abnormal with 2 of following
- FG >=95
- 1 hr >=180
- 2 hr > = 150
- 3 hr >=140
Preeclampsia
Meds ok to use
HTN
Proteinuria
Edema
Labetolol, no ACEI or ARB
HELLP
Hemolysis
Elevated liver enzymes
Low Platelets
Tx seizures in pregnancy
Stay on current meds, Vit K and folate given
Diazepam can be use to break seizures
Warfarin
Ok breastfeeding
Not pregnancy
Anticoagulation during pregnancy
Stop all during active labor and until 6 hrs after delivery
Marijuana
- Maternal risk
- Fetal risks
Mom: minimal
Kid: IUGR, prematurity
Cocaine
- Maternal risk
- Fetal risks
Mom: ARRHYTHMIA, MI, SAH, seizures, stroke, abruptio placentae
Kid: ABRUPTIO PLACENTAE, IUGR, prematurity, facial abnormalities, delayed intellectual development, fetal demise, bowel atresias, congenital malformation heart, limbs, face, GU, microcephaly, cerebral infarctions
Ethanol
- Maternal risk
- Fetal risks
Mom: minimal
Kid: FETAL ALCOHOL SYNDROME, spontaneous abortion, intrauterine fetal demise
Opiods
- Maternal risk
- Fetal risks
Mom: INFECTION (needles), withdrawa, PROM
Kid: Prematurity, IUGR, meconium aspiration, neonatal infections, NARCOTIC WITHDRAWAL (may be fatal)`
Stimulants
- Maternal risk
- Fetal risks
Mom: lack of appetite and malnutrition, arrhythmia, withdrawal depression, HTN
Kid: IUGR, congenital heart defect, cleft palate
Tobacco:
- Maternal risk
- Fetal risks
Mom: ABRUPTIO PLACENTAE, PLACENTAE PREVIA, PROM
Kid: Spontaneous abortion, prematurity, IUGR, intrauterine fetal demise, impaired intellectual development, higher risk of neonatal respiratory infection
`Hallucinogens:
- Maternal risk
- Fetal risks
Mom: Personal enlargement (poor decisions making)
Kid: Possible developmental delays
Fetal alcohol syndrome
Mental retardation IUGR Sensory and motor neuropathy Facial abnormalities- midfacial hypoplasia Growth restriction Renal and cardiac defects Drinking >6 drinks per day
ACEI teratogen effects
Renal- fetal renal tubular dysplasia and renal failure, oligohydramnios
IUGR
Decreased skull ossification
Aminoglycosides teratogen effects
CN VIII damange
Skeletal
Renal
Carbamazepine teratogen effects
Facial IUGR Mental retardation CV NTD Fingernail hypoplasia
Chemo (all classes) teratogen effects
Intrauterine fetal demise Severe IUGR Anatomic- Palate, bones, limbs, genitals, etc Mental retardation Spontaneous abortion Secondary neoplasms
Diazepam teratogen effects
Cleft palate
Renal
Secondary neoplasms
DES teratogen effects
Vaginal and cervical cancer - clear cell adenocarcinoma
Possible infertility
Fluoroquinolones teratogen effects
Cartilage
Heparain teratogen effects
Prematurity
Intrauteine fetal demise
Safer than warfarain
Lithium teratogen effects
Ebstein
OCPS teratogen effects
Spontaneous abortion
Ectopic
Phenobarb teratogen effects
Neonatal withdrawal