GI Flashcards
Pt presents with sudden onset severe, diffuse abd pain. Exam: peritoneal signs, AXR reveals free air under diaphragm. Management?
Emergent laparatomy to repair perforated viscus
Most likely cause of acute lower GI bleed in pts > 40
Diverticulosis
Dx modality used when US equivocal for cholecystitis
HIDA
Risk factors cholithiasis
Fat Female Fertile Forty Flatulent
Inspiratory arrest during palpation of RUQ
Murphys’ acute cholecystitis
Most common cause SBO in pts with no Hx abd surg
Hernia
Most common cause SBO in pts with Hx abd surg
Adhesions
Diarrhea bug: most common
Tx
Campylobacter
Erythromycin
Diarrhea bug: recent abx
C diff
Diarrhea bug: camping
Giardia
Diarrhea bug: Traveler’s
ETEC
Diarrhea bug: Church picnics/mayo -room temp food
-Mechanism of infection
S aureus
Preformed toxin
Diarrhea bug: Uncooked hamburgers
Tx
E coli O157: H7
Abx may worsen due to toxin release as bugs die so hydrate
Diarrhea bug: fried rice
Bacillus cereus
Diarrhea bug: poulty/eggs
Salmonella
Campy - 2nd most common
Diarrhea bug: raw seafood
Vibrio cholerae (COPIOUS WATERY DIARRHEA), HAV
Diarrhea bug: AIDS
Isospora
Crypotosporidium
MAC
Diarrhea bug: Pseudoappendicitis
Yersinia
25 yo Jewish man presents with pain and watery diarrhea after meals, Exam shows fistulas between bowel and skin and nodular lesions on tibias
Crohns
Inflammatory disease of colon with inc risk colon CA
UC
Extraintestinal manifestations of IBD
Uveitis Ankylosing spondylltis Pyoderma gangrenosum Erythema nodosum Primary sclerosing cholangitis
Tx IBD
5ASA and steroids during exacerbation
Difference Mallory Weiss vs Boerhaave
Malloary: superficial in mucosa
Boerhaave: full thickness rupture
Charcot’s triad
RUQ pain
Jaundice
Fever/chills
–Signs of ascending cholangitis
Reynold’s pentad
Charcot’s triad +
Shock
Mental status change
–Signs of suppurative ascending cholangitis
Medical Tx hepatic encephalopathy
dec protein intake
Lactulose
Rifaximin
First step management acute GI bleed
ABC
4 yo with oliguria, petechiae, jaundice after illness with bloody diarrhea. Dx and cause
HUS 2/2 E coli O157: H7
Post HBV exposure Tx
HBV IVIG
Classic causes of drug induced hepatitis
TB meds - RIP
Acetaminophen
Tetracyclines
40 yo obese woman with elevated ALP and bilirubin, pruritis, dark urine, clay colored stools
Biliary tract obstruction
Hernia with highest risk of incarceration – indirect, direct, or femoral
Femoral
50 yo man with Hx alcohol abuse presents with boring epigastric pain that radiates to back and relived by sitting forward. Tx?
Confirm Dx acute pancreatitis with elevated amylase and lipase
NPO, IVF, O2, analgesics, time
Common viral causes of gastroenteritis
Norwalk Coxsackie A1 Echovirus ADenovirus Rotavirus in kids
Bloody diarrhea
Campylobacter C diff (can also be watery) EHEC - 0157: H7 Salmonella Shigella- really bad Yersinia Entamoeba histolytica
Honey, home canning bug
Flaccid paralysis
Tx?
C botulinum
Tx: Botulism antitoxin
Gray pseudomembranes on colonic mucosa
Tx
C diff
Tx: metronidazole or oral vanc
Overcrowding, food or water
Tx
Shigella
Cipro or TMP-SMX if severe
Oysters, watery diarrhea within 24 hrs of eating
Vibrio parahemolyticus
Pork of fresh produce
RLQ pain
Yersinia enterocolitica
Cysts and trophozoites in stool
Tx
Giardia (camping) Entamoeba (poor sanitation
Metronidazole, Paramomycin (Enamoeba only)
Acid fast stain of stool shows parasites
Tx
Cryptosporidium
Nitazoxanide
Undercooked pork, myalgias, periorbital edema, eosinophilia
Tx
Taenia spiralis
Albendazole, mebendazole if bad
Undercooked pork, CNS Sx
Tx
Taenia solium
Praziquantel
Albendazole + steroids if CNS Sx
Hepatitis- fecal oral, usu shellfish; self limited disease, vaccine available for travel
Type of RNA/DNA
Hep A
Picornavirus - ssRNA
Water, fecal oral route; high maternal mortality in pregnant
Type of RNA/DNA
Hep E
Calcivirus - ssRNA
Spread via blood, sexual contact
Complication is chronic hepatitis
Type of virus
Tx
Hep C
Flavivirus- ssRNA
IFN alpha or ribavirin
Spread via blood, sexual contact
Risk of hepatocellular carcinoma, fulminant hepatitis, chronic hepatitis/cirrhosis
Type of virus
Tx
Hep B
IFN alpha or antivirals like lamivudine, adefovir, entecavir
Vaccine available
Hepadnavirus: ds DNA
Requires coexistent Hep B infection
Risk of severe hepatitis/cirrhosis
Type of virus
Hep D
Delta agent - incomplete ssRNA
Tx with Hep B vaccine
HBsAg - surface: neg
HBeAg: neg
Anti-HBs (Ab): pos
Anti-HBc (Ab to core): neg
Vaccinated
HBsAg - surface: neg
HBeAg : neg
Anti-HBs (Ab): neg
Anti-HBc (Ab to core): Positive IgM
Acute infection window 12-20 wks after exposure
HBsAg - surface: Positive
HBeAg : neg
Anti-HBs (Ab): neg
Anti-HBc (Ab to core): positive IgG
Chronic infection with leesser viral replication - good prognosis
HBsAg - surface: positive
HBeAg : positive
Anti-HBs (Ab): neg
Anti-HBc (Ab to core): Positive IgM
Acute infection 4-12 wks postexposure
HBsAg - surface: positive
HBeAg : positive
Anti-HBs (Ab): neg
Anti-HBc (Ab to core): pos IgG
Chronic infection with active viral replication
HBsAg - surface: neg
HBeAg : neg
Anti-HBs (Ab): Positive
Anti-HBc (Ab to core): Positive IgG
Previous infection - recovered
Mg vs Al
Mg: diarrhea
Al: constipation
H2 antagonists
Examples
mechanisms
“tidine”
Reversibly block H2 to inhibit gastric acid secretion
Cimetidine may cause gynecomastia and impotence
PPI
Examples
MEchanism
“prazole”
Irreversibly block parietal cell H/K ATPase to block gastric acid secretion
Most common cause diarrhea adult vs kids
Adult: lactose intolerance
Kids: rotavirus
Type A vs Type B chronic gastritis
A: fundus, autoAB parietal cells causing pernicious anemia, dec gastrin and gastric acid
B: antrum, H pylori, inc gasric acid