Rapid-Fire Facts Flashcards

1
Q

Most common cause of neural tube defects

A

Folate deficiency

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2
Q

Most common cause of congenital malformations in the US

A

Alcohol use during pregnancy

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3
Q

Most common cause of congenital intellectual disability in the US

A

Fetal alcohol syndrome

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4
Q

Hyperflexible joints, arachnodactyly, aortic dissection, lens dislocation

A

Marfan syndrome

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5
Q

Hereditary nephritis, cataracts, sensorineural hearing loss

A

Alport syndrome

“can’t see, can’t pee, can’t hear high C”

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6
Q

Unilateral facial drooping involving the forehead

A

Bells palsy CNVII lesion

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7
Q

Ptosis, miosis, and anhidrosis

A

Horner syndrome

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8
Q

“worst headache of my life”

A

Subarachnoid hemorrhage

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9
Q

Lucid interval following head trauma

A

Epidural hematoma

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10
Q

Bloody CSF on lumbar puncture

A

Subarachnoid hemorrhage

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11
Q

Most common cause of subdural hematoma

A

Rupture of bridging veins

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12
Q

Most common cause of epidural hematoma

A

Rupture of middle meningeal artery

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13
Q

Treatment for absence seizures

A

Ethosuximide

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14
Q

Treatment for tonic-clonic seizures

A

Phenytoin, valproic acid, carbamazepine

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15
Q

Toe extension upon stimulating the sole of the foot with a blunt instrument

A

Babinski reflex

upward going = positive

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16
Q

Hyperreflexia, increased muscle tone, and positive Babinski sign

A

UMN lesion

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17
Q

hyporeflexia, decreased muscle tone, and muscle atrophy

A

LMN lesion

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18
Q

Depigmentation of substantia nigra

A

Parkinson Disease

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19
Q

Chorea, dementia, and atrophy of the caudate and putamen

A

Huntington disease

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20
Q

Eosinophilic inclusions in the cytoplasm of neurons

A

Lewy bodies

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21
Q

Conjugate lateral gaze palsy, with nystagmus and diplopia during lateral gaze

A

internuclear ophthalmoplegia

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22
Q

Degeneration of the dorsal columns

A

Tabes dorsalis

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23
Q

Demyelinating disease in a young woman

A

multiple sclerosis

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24
Q

Mixed upper and lower motor neuron disease

A

ALS

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25
newborn with arm paralysis following a difficult labor
Erb-duchenne palsy
26
most common cause of dementia
Alzheimer disease
27
Second most common cause of dementia
multi-infarct dementia
28
extracellular amyloid deposits in the grey matter
Alzheimer disease - amyloid plaques
29
Intracellular deposits of hyperphosphorylated tau protein
Alzheimer disease - neurofibrillary tangles
30
Intracellular spherical aggregates of tau protein seen on silver stain
Pick diease
31
Amyloid deposits in gray matter of the brain
Alzheimers disease - senile plauques
32
Drooling farmer
Organophosphate poisoning
33
Medical treatment for pheochromocytoma
alpha antagonist like phenoxybenazmine
34
selective alpha-1 antagonist used to treat BPH
Tamsulosin
35
What receptors have a Gq mechanism?
Cutsies HAVe 1 M&M Qc H1, A1, V1, M1 M3
36
What receptors have a Gi mechanism?
MAD 2s M2, A2, D2
37
What receptors have a Gs mechanism?
B1, B2, D1, H2, V2
38
Continuous machinery-like heart murmur
PDA
39
Boot shaped heart
Tetrology of Fallot
40
Rib notching
Coarctation of the aorta
41
Most common congenital cardiac anomaly
VSD
42
Most common congenital cause of early cyanosis
Tetrology of Fallot
43
Bounding pulses, head-bobbing, diastolic murmur
Aortic regurgitation
44
Chest pain, pericardial friction rub, and persistent fever occurring several weeks after an MI
Dressler Syndrome
45
Splinter hemorrhages under the fingernails
Infective endocarditis
46
Retinal hemorrhages with pale centers
Roth spots (infective endocarditis)
47
Heat valve most commonly involved in infective endocarditis
Mitral valve
48
Heart valve most commonly involved in an IV drug user with infective endocarditis
Tricuspid valve
49
Granulomatous nodules in the heart
Aschoff bodies (rheumatic heart disease)
50
Most common primary cardiac tumor in children
Rhabdomyoma
51
Most common primary cardiac tumor in adults
Left atrial myxoma
52
Most common cause of constrictive pericarditis
in the US - Lupus | in developing countries - TB
53
Cold, pale painful digits
Raynaud phenomenon
54
c-ANCA
Granulomatosis with polyangiitis
55
p-ANCA
Microscopic polyangiitis, Churg Strauss
56
Treatment for Buerger disease
Stop smoking!
57
Treatment for temporal arteritis
High dose steroids
58
Bone enlargement (hat doesn't fit anymore), bone pain, arthritis
Paget disease of the bone
59
Vertebral compression fractures
Osteoporosis
60
Positive anterior drawer sign
ACL injury
61
Swollen, hard, painful finger joints
Osteoarthritis
62
Swollen, boggy, painful finger joints
Rheumatoid arthritis
63
Cartilage erosion with polished bone beneath (eburnation of the bone)
Osteoarthritis
64
Swollen, red, acutely painful great toe joint
Gout
65
Positively birefringent rhomboid-shaped crystals
Pseudogout
66
Negatively birefringent needle-shaped crystals
Gout
67
Bamboo spine on x-ray
Ankylosing spondylitis
68
HLA-B27
Seronegative spondyloarthropathies
69
Anti-smith and anti-dsDNA antibodies
Lupus
70
Anti-histone antibodies
drug induced lupus
71
Anti-centromere antibodies
CREST syndrome
72
Anti-topoisomerase antibodies
Diffuse systemic scleroderma
73
Anti-Jo-1 antibodies
Polymyositis
74
Anti-Ro antibodies
Sjogren syndrome
75
Facial rash and Raynaud phenomenon in a young woman
Lupus
76
Arthritis, dry mouth, and dry eyes
Sjogren syndrome
77
Most common cause of death in SLE
Lupus nephropathy/nephritis
78
Keratin pearls on skin biopsy
Squamous cell carcinoma
79
Most common malignant skin tumor
Basal cell carcinoma
80
Most common cancer in men
Prostate cancer
81
Most common cause of urinary obstruction in men
BPH
82
Most common treatment for erectile dysfunction
Phosphodiesterase inhibitor (Sildenafil)
83
Dysplastic cervical cells with enlarged, dark nuclei
Koilocytes (HPV infection)
84
Diethylstilbestrol (DES) exposure
Clear cell adenocarcinoma of the vagina
85
Most common tumor in women
Leiomyoma
86
Most common gynecological malignancy in the US
Endometrial carcinoma
87
Most common gynecological malignancy worldwide
Cervical cancer
88
Chocolate cyst of the ovary
Endometriosis
89
Most common benign ovarian tumor
Serous cystadenoma
90
Most common malignant ovarian tumor
Serous cystadenocarcinoma
91
Disarrayed granulosa cells in eosinophilic fluid
Call-Exner bodies (Granulosa-Theca cell tumors
92
Most common genetic cause of intellectual disability
Trisomy 21 (Down)
93
Second most common genetic cause of intellectual disability
Fragile X Syndrome
94
Horseshoe kidney, congenital heart defects, streak ovaries, and cystic hygroma
Turner syndrome
95
Rocker-bottom feet, clenched hands, microcephaly with prominent occiput and small jaw
Trisomy 18 (Edward syndrome)
96
Most common cancer in women in the US
Breast cancer
97
Most common benign breast tumor
Fibroadenoma
98
Most common malignant breast tumor
infiltrating ductal carcinoma
99
Blue dome cyst in the breast
Fibrocystic change
100
Treatment for ER(+) breast cancer
Tamoxifen
101
Red, itchy, swollen rash on the areola and nipple
Paget Disease
102
Branching, filamentous Gram (+) rods with sulfur granules
Actinomyces israelii
103
Food poisoning due to exotoxin
Staph aureus and B cereus
104
Osteomyelitis in sickle cell disease
Salmonella
105
Most common medication used for UTI prophylaxis
TMP-SMX
106
Most common bacteria in a patient with a struvite kidney stone
Proteus (may be staph)
107
Standard treatment with T. pallidum
Penicillin G
108
Cellulitis from a dog or cat bite
Pasteurella multocida
109
A non-painful, indurated ulcerated genital lesion
Chancre of primary syphilis
110
Moist, smooth, flat white genital lesion
condyloma lata of secondary syphilis
111
Large bull's eye rash
Erythema migrans due to Lyme disease
112
Calcified granuloma in the lung, plus hilar lymphadenopathy
Ghon complex
113
Back pain, fever, night sweats and weight loss
Pott's disease
114
Standard treatment regimen for TB
RIPE - Rifampin, Isoniazid, Pyrazinamide, ethambutol
115
most common etiology of bacterial meningitis in neonates
Group B strep
116
Most common etiology of bacterial meningitis in children
Strep penumo, N. meningitidis
117
Most common etiology of bacterial meningitis in adults
Strep pneumo
118
Osteomyelitis in an IV drug user
Staph aureus, pseudomonas
119
Osteomyelitis in a sickle cell patient
Salmonella
120
Most common reportable STD
Chlamydia
121
Non-painful, indurated, ulcerated genital lesion with exudate
Chancroid
122
Stippled vaginal epithelial cells on a wet prep of vaginal discharge
Clue cells in Bacterial vaginosis
123
Common treatment for syphilis
Penicillin G
124
Common treatment for Trichomonas
Metronidazole
125
Common treatment for Chlamydia
Doxycycline or Azithromycin
126
Common treatment for gonorrhea
Ceftriaxone
127
Dark purple nodules on the skin an HIV patient
Kaposi sarcoma
128
Temporal lobe encephalitis
HSV-1
129
Owl's eye inclusions in organ tissue
CMV
130
Intranuclear eosinophilic droplets
Type A Cowdry bodies - HSV, CMV
131
Aplastic anemia in a sickle cell patient
Parvovirus B19
132
Child with a fever and "slapped cheek" rash on the face that spreads to his body
Fifth disease (Parvovirus B19)
133
Fever, runny nose, cough, conjunctivitis, and diffuse rash
Measles (Rubeola)
134
Small irregular blue-gray spots on the buccal mucosa, surrounded by a base of red
Koplik spots (Measles)
135
Dark purple nodules on the skin in an HIV patient
Kaposi Sarcoma
136
Large cells with owl's eye inclusions
CMV
137
Treatment for CMV
Ganciclovir
138
Most common opportunistic infection in HIV patients
Pneumocystis jirovceii penumonia
139
Drug used to prevent penumocysts pneumonia
TMP-SMX
140
Treatment for oral candidiasis
Nystatin, Fluconazole
141
Most common opportunistic infection in HIV patients
Penumocystis jirovecii
142
Prophylaxis for Cryptococcus in AIDS patients
Fluconazole
143
Prophylaxis for PCP in AIDS patients
TMP-SMX
144
Treatment for systemic candidiasis
Fluconazole (normal patients), Amphotericin B or echinocandin (immunocommpromised patients)
145
Treatment for sporothrix schenckii
Itraconzole oral potassium iodide
146
Ring enhancing brain lesions in an HIV patient
Toxoplasma gondii
147
Treatment for trichomonas vaginalis
Metronidazole
148
Most common protozoal diarrhea
Giardia Lamblia
149
Most common helminth infection in the USA
Enterobius vermicularis (pinworm!)
150
Second most common helminth infection in the USA
Ascaris lumbricoides
151
Anti-IgG antibodies
AKA Rheumatoid factor! | Rheumatoid arthritis
152
Anti-citrullinated protein antibodies (ACPA)
Rheumatoid arthritis, this is more specific for RA than rheumatoid factor
153
Anti-centromere antibodies
CREST syndrome
154
Anti-Scl-70
AKA anti-DNA topoisomerase | Diffuse scleroderma
155
Anti-histone antibodies
Drug induced lupus
156
Antinuclear antibodies (ANA)
Systemic lupus erythematous ANA is not specific
157
Anti-smith antibodies
Systemic lupus erythematous
158
Anti-dsDNA
Lupus nephritis
159
Anti-Jo-1 antibodies
Polymyositis (dermatomyositis)
160
Anti-SSA (anti-Ro)
Sjogren syndrome
161
Anti- SSB (anti-La)
Sjogren syndrome
162
Anti-U1-RNP
(RNP = Ribonucleoprotein) | Mixed connective tissue disease
163
Anti-desmoglein
Pemphigus vulgaris
164
Anti-acetylcholine receptor
Myasthenia gravis
165
Anti-endomysial (anti-transglutaminase)
Celiac Disease
166
Anti-gliadin
Celiac disease
167
Anti-mitochrondrial
Primary biliary cirrhosis
168
Anti-smooth muscle
Autoimmune hepatitis
169
Anti-glutamate decarboxylase
Type 1 DM
170
Anti-thyrotropin receptor
Graves disease
171
Anti-thyroid peroxidase (anti-TPO)
Hashimoto Thyroiditis
172
Anti-thyroglobulin
Hashimoto thyroiditis, Graves disease
173
Anti-basement membrane
Good pastures syndrome
174
c-ANCA
Granulomatosis with polyangiitis (Wegener's)
175
p-ANCA
Pauci-immune crescentic glomerulonephritis Churg-Strauss syndrome Microscopic polyangiitis
176
Eczema, recurrent cold abscesses, high serum IgE
Hyper IgE syndrome (Job Syndrome)
177
Large lysosomal vesicles in phagocytes
Chediak Higashi Syndrome
178
Dysphage, glossitis, iron deficiency anemia
Plummer vinson syndrome
179
Hematemesis with retching
Mallory-Weiss Tear
180
Specialized columnar epithelium seen in a biopsy from the distal esophagus
Barrett's esophagus
181
Biopsy of a patient with esophagitis reveals large pink intranuclear inclusions and host cell chromatin that is pushed to the edge of the nucleus
HSV infection
182
Biopsy of a patient with esophagitis reveals enlarged cells, intracuclear and cytoplasmic inclusions, and a clear perinuclear halo
CMV infection
183
An esophageal biopsy reveals a lack of ganglion cells between the inner and outer muscular layers
Achalasia
184
Protrusion of the mucosa in the upper esophagus (webs)
Plummer-Vinson Syndrome
185
Outpouching of all layers of the esophagus found just above the LES
Epiphrenic diverticulum
186
Goblet cells seen in the distal esophagus
Barrett esophagitis
187
A PAS stain on a biopsy obtained from a patient with esophagitis reveals hyphate organisms
Candida esophagitis
188
Esophageal pouch found in the upper esophagus
Zenker diverticulum
189
Stomach biopsy reveals neutrophils above the basement membrane, loss of surgace epithelium, and fibrin-containing purulent exudate
Acute gastritis
190
Stomach biopsy reveals lymphoid aggregates in the lamina propria, columnar absorptive cells, and atrophy of glandular structures
Chronic gastritis
191
Diffuse thickening of gastric folds, elevated serum gastrin levels, biopsy reveals glandular hyperplasia without foveolar hyperplasia
Zollinger-Ellison syndrome
192
Mucin filled cell with a peripheral nucleus
Signet ring cell | Seen in gastric cancer, lobular carcinoma in situ
193
Most common type of stomach cancer
Adenocarcinoma
194
Ovarian metastasis from gastric cancer
Krukenberg tumor
195
Gastric ulcerations and high gastric levels
Zollinger-Ellison tumor
196
Acute gastric ulcer associated with elevated ICP or head trauma
Cushing ulcer
197
Acute gastric ulcer associated with severe burns
Curling ulcer
198
Weight loss, diarrhea, arthritis, fever, adenopathy and hyperpigmentation
Whipple disease
199
Anti-transglutaminase/anti-gliadin/anti-endomysial antibodies
Celiac Disease
200
Vitamin given to pregnant women to prevent neural tube defects
Folic acid
201
Most common surgical emergency
Appendicitis
202
Severe RLQ pain with rebound tenderness
McBurney's point
203
Most common cancer of the appendix
Carcinoid tumor
204
GI hamartomas, hyperpigmentation of the mouth and hands
Peutz-Jeghers syndrome
205
Multiple colon polyps, osteomas, soft tissue tumors
Gardner syndrome
206
"Apple core" lesion on barium enema
Colon cancer
207
Most common site of colonic diverticula
Sigmoid colon
208
"String sign" on contrast X ray
Crohn's disease
209
"Lead pipe" appearance of colon on contrast X-ray
Ulcerative colitis
210
Painless jaundice
Pancreatic cancer - esp in head of pancrease
211
Most common cause of acute pancreatitis
Gallstones and alcohol
212
Most common cause of chronic pancreatitis
Alcohol abuse
213
Severe hyperbilirubinemia in a neonate
Crigler Najjar syndrome (Type I)
214
Mild, benign hyperbilirubinemia
Gilbert Syndrome
215
Triglyceride accumulation in hepatocytes
Fatty liver disease
216
Eosinophilic inclusions in the cytoplasm of hepatocytes
Mallory bodies
217
Cancer closely linked to cirrhosis
Hepatocellular carcinoma
218
Hepatomegaly, abdominal pain, ascites
Budd-Chiari Syndrome remember with Budd Chiari there is ABSENT JVD
219
Green/yellow corneal deposits
Wilson disease
220
Low serum ceruloplasmin
Wilson disease
221
Cirrhosis, diabetes, and hyperpigmentation
Hemochromatosis
222
Cholelithiasis
Gallstones
223
Cholecystitis
Inflammation/infection of the gallbladder
224
Cholangitis
Inflammation/infection of the biliary tree
225
Choledocholithiasis
Gallstones in the bile ducts
226
Charcot's triad
Jaundice, fever, RUQ pain
227
Reynolds triad
Charcot's triad + hypotension and altered mental status
228
Chronic sinusitis, infertility and situs inversus
Kartagener syndrome
229
Elevated D-dimers
PE, DVT | Clotting!
230
Hypercoagulability, endothelial damage, stasis of blood
Virchow's triad
231
Blue bloater
Hypoxemia, hypercapnia (Chronic bronchitis)
232
Pink puffer
Dyspnea, Hyperventilation (Emphysema)
233
Curschmann's spirals
Shed epithelium from mucus plugs (asthma)
234
Most common cause of pulmonary hypertension
COPD
235
Bilateral hilar adenopathy and uveitis
Sarcoidosis
236
Vasculitis and glomerulonephrtisis
Goodpastures, Wegener's
237
Anti-glomerular basement membrane antibodies
Goodpasture's
238
Honeycomb lung on X-ray
Interstitial fibrosis
239
"tennis-racket" shaped cytoplasmic organelles
Birbeck granules
240
Iron-containing nodules in the alveolar septum
Ferruginous bodies (suspect asbestosis)
241
Lung cancer associated with SIADH
Small cell lung cancer
242
Tumor associated with horner syndrome
Pancoast tumor
243
A boy with self-mutilating behavior, intellectual disability and gout
Lesch-nyhan syndrome
244
Orotic acid in the urine and elevations in serum ammonia
OTC deficiency
245
Orotic acid in the urine and no elevations in serum ammonia
Orotic aciduria
246
Megaloblastic anemia that does not improve with folate or B12
Orotic aciduria
247
bluish colored lines on the gingivae
Lead poisoning (bruton's lines)
248
treatment of choice for rickets or osteomalacia
Vitamin D
249
Swollen gums, poor wound healing, bleeding mucous membranes, and spots on the skin
Scurvy (Vitamin C deficiency)
250
Most common vitamin deficiency in the US
Folate deficiency
251
Hypersegmented neutrophils
Megaloblastic anemia (Folate and/or B12)
252
Dilated cardiomyopathy, edema and polyneuropathy
Wet Beri Beri (Thiamine Vit B1 deficiency)
253
most common medication for ADHD
Methylphenidate (Ridalin)
254
Most common medication for bulimia nervosa
SSRIs (example: Fluoxetine)
255
medical treatment for alcohol withdrawal
Benzodiazepine (Example: -pam, or Chlordiazepoxide)
256
Most effective treatment for alcohol abuse
AA (alcoholics anonymous)
257
Atrophy of the mammillary bodies
Wernicke's encephalopathy
258
Treatment for central DI
Desmopressin
259
Treatment for nephrogenic DI
HCTZ, indomethacin, amiloride
260
Treatment for lithium-induced nephrogenic DI
Amiloride
261
Nodular hyaline deposits in the glomeruli
Kimmelstiel-Wilson nodules (Diabetic nephropathy)
262
Glomerulonephritis plus pulmonary vasculitis
Granulomatosis with polyangiitis | Goodpastures syndrome
263
Red cell casts
Acute glomerulonephritis
264
Waxy casts
Chronic renal failure
265
Thyroid-like appearance of kidney
Chronic pyelonephritis
266
Most common renal tumor
Renal cell carcinoma
267
Most common type of renal stone
Calcium stones
268
Type of renal stone associated with Proteus vulgaris
Struvite stones
269
Inability to breast feed, amenorrhea, cold intolerance
Sheehan syndrome
270
Infertility, galactorrhea, and bitemporal hemianopsia
Prolactinoma
271
What are the most common causes of Cushing Syndrome?
Exogenous steroid use Ectopic ACTH secretion ACTH secreting pituitary Adenoma (Cushing Disease) Adrenal tumor that secretes cortisol
272
most common tumor of the adrenal
Benign, non-functioning adrenal adenoma
273
Most common tumor of the adrenal medulla (in adults)
Pheochromocytoma
274
Most common tumor of the adrenal medulla (in children)
Neuroblastoma
275
Most common cause of primary hyperaldosteronism
Adrenal adenoma
276
Medical treatment for hyperaldosteronism
Spironolactone or eplerenone
277
Medical treatment for pheochromocytoma
non-selective alpha blocker (phenoxybenzamine, phentolamine)
278
Pheochromocytoma, medullary thyroid cancer and hyperparathyroidism
MEN2A
279
Pheochromocytoma, medullary thyroid cancer, mucosal neuromas
MEN2B
280
Adrenal disease associated with skin hyperpigmentation
Addisons disease
281
Hypertension, hypokalemia, metabolic alkalosis
Hyperaldosteronism (Conn's syndrome)
282
most common thyroid cancer
Papillary carcinoma
283
Cold intolerance
Hypothyroid
284
Enlarged thyroid cells with ground-glass nuclei
Papillary cancer of the thyroid
285
Standard treatment for DKA
IV fluids, IV insulin, K+ replacement
286
Standard treatment for Type I DM
Insulin
287
Standard treatment for type 2 DM
Low carb diet, weight loss, oral hypoglycemic drugs, insulin
288
Most common cause of hypercalcemia
Primary hyperparathyroidism
289
Most common cause of primary hyperparathyroidism
Parathyroid adenoma
290
Most common cause of secondary hyperparathyroidism
Chronic renal failure (hypocalcemia)
291
Most common cause of hypoparathyroidism
Accidental parathyroidectomy (during thyroid surgery)
292
Facial muscle spasm when tapping on the cheek
Chvostek sign
293
Parathyroid, pancreatic, and pituitary tumors
MEN Itic anemia
294
Preferred anticoagulant for immediate anticoagulation
heparin or LMWH
295
Preferred anticoagulant for long term anticoagulation
Warfarin
296
Preferred anticoagulant during pregnancy
heparin or LMWH
297
Causes of hypochromic, microcytic anemia
iron deficiency, thalassemia, lead posioning
298
Hypersegmented neutrophils
Megaloblastic anemia
299
Skull x-ray shows a hair-on-end appearance
Marrow hyperplasia (beta thalassemia or sickle cell disease)
300
Basophilic stippling of RBCs
Lead posioning
301
painful cyanosis of the fingers and toes, with hemolytic anemia
cold autoimmune hemolytic anemia
302
Red urine in the morning, and fragile RBCs
PNH
303
Autosplenectomy
Sickle cell disease
304
Basophilic nuclear remnants in RBCs
Howell Jolly bodies
305
drug used to treat sickle cell disease
hydroxy urea - increases HbF | inhibits ribonucleotide reductase - decreases DNA synthesis
306
antiplatelet antibodies
Immune thrombocytopenia
307
Bleeding disorder with gpIb deficiency
Bernard soulier disease
308
Most common inherited bleeding disorder
von Willebrand disease
309
cancer most commonly associated with a non-infectious fever
Hodgkin lymphoma
310
Sheets of lymphoid cells with a "starry sky" appearance
Burkitt lymphoma
311
Large B cells with bilobed nuclei and prominent owl's eye inclusions
Reed Sternberg cells
312
"smudge" cells
CLL
313
"Punched out" lytic bone lesions
multiple myeloma
314
RBCs clumped together like a stack of coins
Rouleaux formation (multiple myeloma)
315
Monoclonal antibody spike
Multiple myeloma, MGUS, Waldenstrom macroglobulinemia
316
Reddish pink rods in the cytoplasm of leukemic blasts
Auer rods (AML)
317
Anti-microsomal antibody
Hashimoto thyroiditis