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Drug Reactions Flashcards

1
Q

Coronary Vasospasm

A

Cocaine, Sumatriptan, ergot alkaloids

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2
Q

Cutaneous Flushing

A

VANComycin, Adenosine, Niacin, Ca Channel blockers

“VANC”

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3
Q

Dilated cardiomyopathy

A

Doxorubicine (Adriamycin), Daunorubicin

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4
Q

Torsades de pointes

A

Class III potassium channel blockers (sotalol), Class IA sodium channel blockers (quinidine), macrolides, haloperidol, chloroquine, protease inhibitors

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5
Q

Agranulocytosis

A

Cloazpine, Carbamazepine, Colchicine, Propylthiouracil, Methimazole, Dapsone

“Agranulocytosis Could Certainly Cause Pretty Major Damage”

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6
Q

Aplastic anemia

A

Chloramphenicol, benzene, NSAIDs, propylthiouracil, methimazole

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7
Q

Thrombocytopenia

A

Heparin (HIT), cimetidine

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8
Q

Direct coombs positive hemolytic anemia

A

methyldopa, penicillin

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9
Q

Gray baby syndrome

A

Chloramphenicol

This is due to the baby having immature UDP glucuronidase, so the drug can’t be metabolized appropriately

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10
Q

Hemolysis in G6PD-deficienct patient

A

Isoniazid, Sulfonazmides, Primaquine, Aspirin, Ibuprofen, Nitrofurantoin

“hemolysis IS PAIN”

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11
Q

Megaloblastic anemia

A

Phenytoin, Methotrexate, Sulfa drugs

“having a BLAST with PMS”

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12
Q

Thrombotic complications

A

OCPs

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13
Q

Cough

A

ACE inhibitors

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14
Q

Pulmonary fibrosis

A

Bleomycin, Amiodarone, Busulfan

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15
Q

Acute cholestatic hepatitis, jaundice

A

Erythromycin

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16
Q

Focal to massive hepatic necrosis

A

Halothane, Amanita phalloides, Valproic acid, Acetaminophen (high doses)

“liver HAVAc”

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17
Q

Hepatitis

A

Isoniazid

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18
Q

Pseudomembranous colitis

A

Clindamycin, ampicillin

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19
Q

Adrenocortical insufficiency

A

Glucocorticoid withdrawal

20
Q

Gynecomastia

A

Spironolactone, Digitalis, Cimetidine, chronic Alcohol use, estrogens, Ketoconazole

“Some Drugs Create Awkward Knockers”

21
Q

Hot flashes

A

Tamoxifen, clomiphene

22
Q

Hyperglycemia

A

Niacin, tacrolimus, protease inhibitors, HCTZ, corticosteroids

23
Q

Hypothyroidism

A

Lithium, amiodarone, sulfonamides

24
Q

Fat redistribution

A

Glucocorticoids, protease inhibitors

25
Q

Gingival hyperplasia

A

Phenytoin, verapamil

26
Q

Gout

A

Furosemide, thiazides, niacin, cyclosporine

27
Q

Myopathies

A

Fibrates, Niacin, Colchicine, Hydroxychloroquine, Interferon-alpha, Penicillamine, Statins, Glucocorticoid

“Fish N CHIPS Give you MYOPATHIES”

28
Q

Osteoporosis

A

Corticosteroids, heparin

29
Q

Photosensitivity

A

Sulfonamides, Amiodarone, Tetracycline

“SAT for a PHOTO”

30
Q

Stevens-Johnson syndrome (Rash)

A

Penicillin, Ethosuximide, Carbamazepine, Sulfa drugs, Lamotrigine, Allopurinol, Phenytoin, Phenobarbital

“bad RASH after a PEC SLAPP”

31
Q

SLE-like syndrome

A

Hydralazine, Isoniazid, Procainamide, Phenytoin

32
Q

Teeth (kids)

A

Tetracyclines

33
Q

Tendonitis, tendon rupture, and cartilage damage

A

Fluoroquinolones

34
Q

Diabetes insipidus

A

Lithium, demeclocycline

35
Q

Fanconi’s syndrome

A

Expired tetracycline

36
Q

Hemorrhagic cystitis

A

Cyclophosphamide, ifosfamide (prevent by coadministering with mesna)

37
Q

Interstitial nephritis

A

Methicillin, NSAIDs, Furosemide

38
Q

SIADH

A

Carbamazepine, cyclophosphamide

39
Q

Cinchonism

A

Quinidine, quinine

40
Q

Parkinson-like syndrome

A

antipsychotics, reserpine, metoclopramide

41
Q

Seizures

A

Isoniazid, Buproprion, Imipenem/cilastatin, Tramadol, Enflurane, Metoclopramide

“with SEIZURES, I BITE My tongue”

42
Q

Tardive dyskinesia

A

Antipsychotics

43
Q

Antimuscarinic

A

Atropine, TCAs, H1 blockers, neuroleptics

44
Q

Disulfiram-like reaction

A

Metronidazole, certain cephalosporins, procarbazine, first-generation sulfonylureas

45
Q

Nephrotoxicity/ototoxicity

A

Aminoglycosides, vancomycin, loop diuretics, cisplatin

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