Random Psych Flashcards
Presents with:
Mild depressive symptoms + hypomanic symptoms
lasting ≥ 2 years
cyclothymic disorder
Presents with Diaphoresis, Dilated eyes, Tremors, (hyperreflexia), mental agitation, and even diarrhea
Serotonin syndrome
Emotionally triggered loss of muscle tone
Cataplexy
REM sleep behavior disorder typically occur during the _____ of the sleep period
first third
Anorexia often associated with what 2 illnesses?
OCD
MDD
What 2 elements distinguish Anorexia from Bulimia?
Low BMI (<18.5) Caloric Intake Restriction
Cocaine coronary vasospams can cause (3) complications
MI
stroke
ischemic colitis
Medication that helps reduce self-mutilation
Naltrexone
What is Hypercarotonemia?
yellow pigmentation of the skin (xanthoderma) and increased beta-carotene levels in the blood.
(seen in Anorexia; yellowing skin/palms & low T3)
List S/X of antidepressant discontinuation syndrome
Fatigue
Insomnia
Muscle Aches
Flu like s/x
First thing when a child shows neuro-developmental problems?
Screen for Hearing loss
can cause: Social, Language, Speech delays
Where is Serotonin made?
Raphe Nucleus
Agression, Delusions, paranoia, hyperthermia, dilated pupils, Tachycardia &/or HTN
(Not amphetamines/cocaine)
Bath Salts (Cathinones)
*NEG Urine Tox screen
What is Vaginismus?
involuntary vaginal muscle spasms
*genitopelvic pain disorder
MOA of Tetrabenazine used for Tourettes
VMAT2- Inhibitor
Where is Acetylcholine made
Basal nucleus of Meynert
Where is GABA made?
Nucleus Accumbens
Where is NE made
Locus Cereleus
Where is Dopamine made
Ventral Tegmentum; Substantia Nigra Pars Compacta
Amantadine MOA
For Parkinsonism
weak NMDA receptor
*Orthostatic hypotension/anxiety/ataxia
Cyproheptadine MOA
For Serotonin Syndrome
Anti-5HT2
Anti-Histamine
TCA MOA
Anti- alpha1
Anti-H1
Anti- Ach (Anti-Cholinergic)
NE & 5HT re-uptake inhibitor
Trazadone MOA
Anti-5HT2
Anti- alpha1
Anti-H1
Serotonin re-uptake inhibitor
D2 is linked to what GPCR?
Gi
Anti-psychotics inhibit Gi = increase cAMP
Which Antipsychotics have the strongest Anti-Histamine and Alpha1 effects?
Low Potency TYPICAL Antipsychotics
Linezolid (antibiotic) has ____ activity
MOA-1
Mirtazepine Antidepressant MOA
Anti- alpha2 **
Anti-H1
Anti- 5HT2 & 5HT3 ***
Increase release of NE & Serotonin
Atypical antipsychotics block
D2
Seretonin 2A
H1
Alpha1 (orthostatic hypotension)
Oppositional defiant disorder treatment
Parent Management Therapy
Behavior mod/ conflict management
Benztropine MOA
Inhibition of dopamine transporters
&
antimuscarinic/antihistaminic effects
How can lithium become toxic?
Hypovolemia (diuretics) = ↑ Na+ reabsorption = ↑ lithium = danger of toxicity
Akithesia can be caused by (2)
Antipsychotics or Parkinson treatment
Asterixis (wrist flapping) associated with (3)
Hepatic Encephalopathy
Wilson’s disease
Metabolic Derangements
Athetosis (snake like writhing movements in the fingers especially) seen in what illness?
Huntington
Chorea (purposeless jerking involuntary movements) seen in what illness?
Huntington
Resting tremor in Parkinson is due to a lesion where in the brain?
Substantia Nigra
Restless leg syndrome worsens at night/ with rest and improves with movement associated with (4)
Pregnancy
Parkinson
CKD
Iron deficiency
*treat with Pramipexole/Ropinirole D2 agonist
Dementia can be cause by ____ deficiency or ____-thyroidism
Vit B12 (Cobalamin)
hypothyroidism
Inhibition of the ____ in the brain causes Parkinson
Thalamus
2 Histological findings of Parkinson
Depigmentation of Substantia Nigra (loss of dopaminergic neurons)
Lewy bodies (Eosinophilic inclusions of alpha syn)
Can present with Agression, Depression, Dementia
Huntington
Huntington is due to a lesion(s) where in the brain?
Caudate/ Putamen
Huntington has what imbalance of Neurotransmitters
↑ Dopamine
↓ GABA
↓ Ach
List 3 histological findings in Alzheimer’s
Hirano bodies (hippocampus- pink rods)
Senile Plaques (amyloid Beta)
Neurofibrillary tangles (Hyper Phosphorylated Tau-microtubules)
List 4 Gross histological findings in Alzheimer’s
Cortical Atrophy
Hipocampus Atrophy
Narrowing Gyri
Widening Sulci
List 2 histological findings in Pick’s Frontal-temporal dementia
Round silver stain Hyper Phosphorylated Tau protein
(pick bodies)
Ubiquitinated TDP-43
Histological finding associated with HIV dementia?
Macrophages (Oligodendrocytes) fuse to make
GIANT CELLS
Brain imaging shows Focal demyelinated plaques, periventricular calcifications, and axonal sparing
Multiple Sclerosis
Ataxia, Myoclonus, ↓ school performance
Demyelination, Gliosis, Oligoclonal bands IgG in CSF.
Subacute Sclerosing Pan Encephalitis (SSPE)
2/2 Measels (viral capsid accumulates)
Idiopathic cranial HTN (aka Pseudotumor cerebri) is an
↑ICP usually seen in Obese women with recurrent Headaches, Papilledema +/- Recurrent Infections.
Associated with ____
Cerebral Venous Sinus Stenosis
*LP puncture relieves HA