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Psychosis Flashcards

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1
Q

stronger 5-HT2, α-1, and H1 antagonism

weaker D2 receptor antagonism

A

Atypical antipsychotics (neuroleptic)

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2
Q

Fewer side effects of sedation and hypotension

Antipsychotics (3)

A

Haloperidol
Fluphenazine
Perphenazine

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3
Q

Are antipsychotics fat soluble?

A

Yes, highly fat soluble

results in storage for long time in body fat

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4
Q

Clinical uses for Antipsychotics (5)

A 
schizophrenia
psychosis
acute mania (temporary)
Tourettes
hiccups (persistent > 48 hours for > 1 month)
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5
Q 
Antipsychotic extrapyramidal system (EPS) side effects
4 hours = 
4 days = 
4 days to 4 weeks = 
4 months =
A

acute dystonia (neck/eye/swallow rigidity)
akathisia
Parkinsonism
tardive dyskinesia

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6
Q

valbenazine and deutetrabenazine MOA

A

vesicular monoamine transporter 2 inhibitor

VMAT: regulates the packaging and release of dopamine, NE & 5HT from neuronal vesicles into the synapse

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7
Q

fluphenazine (antipsychotic) can cause

A

hypothermia

messes w/ hypothalamus

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8
Q 
low potency Antipsychotics have:
↓ EPS side effects
↑ non-specific side effects due to:
\_\_\_ receptor antagonism
Alpha 1 receptor antagonism
Histamine receptor antagonism
A

Muscarinic

dry mouth/constipation/vision problems

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9
Q 
low potency Antipsychotics have:
↓ EPS side effects
↑ non-specific side effects due to:
\_\_\_ receptor antagonism
Alpha 1 receptor antagonism
Muscarinic receptor antagonism
A

Histamine

sedation

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10
Q 
low potency Antipsychotics have:
↓ EPS side effects
↑ non-specific side effects due to:
\_\_\_ receptor antagonism
Histamine receptor antagonism
Muscarinic receptor antagonism
A 
Alpha 1
(orthostatic hypotension/ sexual dysfxn)
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11
Q

dopamine normally inhibits ___ secretion

A

prolactin

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12
Q 
High fever
Muscle rigidity
Unstable/weird vitals
Increased CK, K+, and WBC's
\+/- Metabolic acidosis or RBCs in pee
A

NMS

recent antipsychotic use

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13
Q
  • High potency antipsychotic
  • Usually first line
  • Hyperprolactinemia
  • Weight gain
A

Risperidone

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14
Q

Atypical antipsychotic
Severe weight gain
Very sedating

A

Olanzipine

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15
Q

Atypical Antipsychotic
Minimal to no weight gain
Increased QTc (Torsades risk)

A

Ziprasidone

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16
Q

Low potency Antipsychotic
Sedating
Weight gain
Useful in bipolar depression and augmentation of major depression therapy

A

Quetiapine

17
Q

Atypical antipsychotic
Minimal weight gain
Useful in biploar depression

A

Lurasidone

18
Q

D2 partial agonist
Augmentation of major depression therapy
Minimal weight gain
Atypical antipsychotic

A

Aripripazole

Psych Rotation (7 decks)

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