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First Aid Heme-Onc Chapter > Random Chemo Drugs > Flashcards

Random Chemo Drugs Flashcards

1
Q

MoA of Cisplatin and Carboplatin

A

Cross-Link DNA

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2
Q

Use of Cisplatin and Carboplatin

A

Testicular, Bladder, Ovary, and Lung Carcinomas

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3
Q

Tox of Cisplatin and Carboplatin

A

Nephrotoxicity
Ototoxicity
Peripheral Neuropathy

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4
Q

How do you prevent Cisplatin and Carboplatin nephrotoxicity? (2)

A

amifostine (free radical scavenger)

saline diuresis

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5
Q

MoA of Etoposide, Teniposide

A

Topoisomerase II inhibitor -> DNA degradation

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6
Q

clinical use of Etoposide, Teniposide

A

testicular Cancer and Small Cell Cancer

Leukemia/Lymphoma

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7
Q

Tox of Etoposide, Teniposide

A

Myelosuppression and Alopecia

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8
Q

MoA of irinotecan, Topotecan

A

Topoisomerase I inhibitor -> prevents DNA unwinding and replication

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9
Q

use of Irinotecan

A

Colon Cancer

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10
Q

use of topotecan

A

ovarian cancer and small cell lung cancer

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11
Q

tox of irinotecan, Topotecan

A

severe myelosuppression and diarrhea

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12
Q

MoA of Hydroxyurea

A

Inhibits ribonucleotide reductase -> DNA Synthesis

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13
Q

use of Hydroxyurea

A

Melanoma
CML
Sickle Cell Disease (increases HbF)

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14
Q

Tox of Hydroxyurea

A

severe myelosuppression

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15
Q

What are the most commonly used corticosteroids in cancer chemotherapy?

A

Prednisone, Prednisolone

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16
Q

What chemo drug is a monoclonal Ab against VEGF?

A

Bevacizumab

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17
Q

use of Bevacizumab

A

solid tumors

colorectal cancer and renal cell carcinoma

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18
Q

Tox of Bevacizumab

A

hemorrhage, blood clots, impaired wound healing

19
Q

What chemo drug is an EGFR tyrosine kinase inhibitor?

A

Erlotinib

20
Q

Use of Erlotinib

A

non-small cell lung cancer

21
Q

Tox of Erlotinib

A

Rash

22
Q

What chemo drug is a monoclonal Ab against EGFR?

A

Cetuximab

23
Q

use of Cetuximab

A

Stage IV colorectal cancer (wild-type KRAS)

head and neck cancer

24
Q

Tox of Cetuximab

A

Rash
elevated LFTs
diarrhea

25
Q

What chemo drug is a BCR-ABL tyrosine kinase Inhibitor?

A

Imatinib

26
Q

What chemo drug is a c-kit inhibitor?

A

Imatinib

27
Q

Use of Imatinib

A

CML and GI Stromal Tumors

28
Q

Tox of Imatinib

A

Fluid Retention

29
Q

What chemo drug is a monoclonal antibody against CD20?

A

Rituximab

30
Q

Where is CD20 found?

A

found on most B-Cell Neoplasms

31
Q

use of Rituximab

A

Non-Hodgkin Lymphoma
CLL
ITP
Rheumatoid Arthritis

32
Q

Tox of Rituximab

A

increased risk of progressive multifocal encephalopathy

33
Q

MoA of Tamoxifen, Raloxifene

A

Selective estrogen receptor modulators (SERMs)—receptor antagonists in breast and agonists in bone. Block the binding of estrogen to ER ⊕ cells

34
Q

use of Tamoxifen, Raloxifene

A

Breast cancer treatment (tamoxifen only) and prevention

35
Q

What chemo drug is used to treat breast cancer AND osteoporosis?

A

Raloxifene also useful to prevent osteoporosis

36
Q

Tox of Tamoxifen

A

partial agonist in endometrium, which the risk of endometrial cancer; “hot flashes.”

37
Q

Tox of Raloxifene

A

no in endometrial carcinoma because it is an estrogen receptor antagonist in endometrial tissue.

38
Q

Tamoxifen and Raloxifene increased the risk of what?

A

both increase risk of thromboembolic events (DVT, PE)

39
Q

What chemo drug is a monoclonal Ab against HER-2 (c-erbB2) tyrosine kinase receptor?

A

Trastuzumab (Herceptin)

40
Q

Use of Trastuzumab (Herceptin)

A

HER-2 + breast cancer and gastric cancer

41
Q

Tox of Trastuzumab (Herceptin)

A

“heartceptin” damages the heart

Cardiotoxicity

42
Q

What chemo drug is a BRAF oncogene inhibitor?

A

Vemurafenib

43
Q

Vemurafenib is used for what?

A

V600E BRAF mutated metastatic melanoma

First Aid Heme-Onc Chapter (8 decks)

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