Random Chemo Drugs

Question 1

MoA of Cisplatin and Carboplatin

Answer 1

Cross-Link DNA

Question 2

Use of Cisplatin and Carboplatin

Answer 2

Testicular, Bladder, Ovary, and Lung Carcinomas

Question 3

Tox of Cisplatin and Carboplatin

Answer 3

Nephrotoxicity
Ototoxicity
Peripheral Neuropathy

Question 4

How do you prevent Cisplatin and Carboplatin nephrotoxicity? (2)

Answer 4

amifostine (free radical scavenger)

saline diuresis

Question 5

MoA of Etoposide, Teniposide

Answer 5

Topoisomerase II inhibitor -> DNA degradation

Question 6

clinical use of Etoposide, Teniposide

Answer 6

testicular Cancer and Small Cell Cancer

Leukemia/Lymphoma

Question 7

Tox of Etoposide, Teniposide

Answer 7

Myelosuppression and Alopecia

Question 8

MoA of irinotecan, Topotecan

Answer 8

Topoisomerase I inhibitor -> prevents DNA unwinding and replication

Question 9

use of Irinotecan

Answer 9

Colon Cancer

Question 10

use of topotecan

Answer 10

ovarian cancer and small cell lung cancer

Question 11

tox of irinotecan, Topotecan

Answer 11

severe myelosuppression and diarrhea

Question 12

MoA of Hydroxyurea

Answer 12

Inhibits ribonucleotide reductase -> DNA Synthesis

Question 13

use of Hydroxyurea

Answer 13

Melanoma
CML
Sickle Cell Disease (increases HbF)

Question 14

Tox of Hydroxyurea

Answer 14

severe myelosuppression

Question 15

What are the most commonly used corticosteroids in cancer chemotherapy?

Answer 15

Prednisone, Prednisolone

Question 16

What chemo drug is a monoclonal Ab against VEGF?

Answer 16

Bevacizumab

Question 17

use of Bevacizumab

Answer 17

solid tumors

colorectal cancer and renal cell carcinoma

Question 18

Tox of Bevacizumab

Answer 18

hemorrhage, blood clots, impaired wound healing

Question 19

What chemo drug is an EGFR tyrosine kinase inhibitor?

Answer 19

Erlotinib

Question 20

Use of Erlotinib

Answer 20

non-small cell lung cancer

Question 21

Tox of Erlotinib

Answer 21

Rash

Question 22

What chemo drug is a monoclonal Ab against EGFR?

Answer 22

Cetuximab

Question 23

use of Cetuximab

Answer 23

Stage IV colorectal cancer (wild-type KRAS)

head and neck cancer

Question 24

Tox of Cetuximab

Answer 24

Rash
elevated LFTs
diarrhea

Question 25

What chemo drug is a BCR-ABL tyrosine kinase Inhibitor?

Answer 25

Imatinib

Question 26

What chemo drug is a c-kit inhibitor?

Answer 26

Imatinib

Question 27

Use of Imatinib

Answer 27

CML and GI Stromal Tumors

Question 28

Tox of Imatinib

Answer 28

Fluid Retention

Question 29

What chemo drug is a monoclonal antibody against CD20?

Answer 29

Rituximab

Question 30

Where is CD20 found?

Answer 30

found on most B-Cell Neoplasms

Question 31

use of Rituximab

Answer 31

Non-Hodgkin Lymphoma CLL ITP Rheumatoid Arthritis

Question 32

Tox of Rituximab

Answer 32

increased risk of progressive multifocal encephalopathy

Question 33

MoA of Tamoxifen, Raloxifene

Answer 33

Selective estrogen receptor modulators (SERMs)—receptor antagonists in breast and agonists in bone. Block the binding of estrogen to ER ⊕ cells

Question 34

use of Tamoxifen, Raloxifene

Answer 34

Breast cancer treatment (tamoxifen only) and prevention

Question 35

What chemo drug is used to treat breast cancer AND osteoporosis?

Answer 35

Raloxifene also useful to prevent osteoporosis

Question 36

Tox of Tamoxifen

Answer 36

partial agonist in endometrium, which the risk of endometrial cancer; “hot flashes.”

Question 37

Tox of Raloxifene

Answer 37

no in endometrial carcinoma because it is an estrogen receptor antagonist in endometrial tissue.

Question 38

Tamoxifen and Raloxifene increased the risk of what?

Answer 38

both increase risk of thromboembolic events (DVT, PE)

Question 39

What chemo drug is a monoclonal Ab against HER-2 (c-erbB2) tyrosine kinase receptor?

Answer 39

Trastuzumab (Herceptin)

Question 40

Use of Trastuzumab (Herceptin)

Answer 40

HER-2 + breast cancer and gastric cancer

Question 41

Tox of Trastuzumab (Herceptin)

Answer 41

"heartceptin" damages the heart | Cardiotoxicity

Question 42

What chemo drug is a BRAF oncogene inhibitor?

Answer 42

Vemurafenib

Question 43

Vemurafenib is used for what?

Answer 43

V600E BRAF mutated metastatic melanoma