Microtubule Inhibitors Flashcards
1
Q
MoA of Paclitaxel and other Taxols
A
Hyperstabilize polymerized microtubules in M phase so that mitotic spindle cannot break down (anaphase cannot occur)
2
Q
Use of Paclitaxel and other Taxols
A
Ovarian and Breast Carcinomas
3
Q
Tox of Paclitaxel and other Taxols
A
Myelosuppression
Neuropathy
Hypersensitivity
4
Q
MoA of Vincristine, Vinblastine (Vinca alkaloids)
A
Bind β-tubulin and inhibit its polymerization into microtubules -> prevent mitotic spindle formation (M-phase arrest)
5
Q
Use of Vinblastine
A
Hodgkin Lymphoma
6
Q
Use of Vincristine
A
Non-Hodgkin Lymphoma
7
Q
Tox of Vincristine, Vinblastine
A
Neurotoxicity (areflexia, Peripheral Neuritis) Paralytic Ileus (constipation)
