Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

First Aid Heme-Onc Chapter > Porphyrias > Flashcards

Porphyrias Flashcards

1
Q

Lead Poisoning inhibits what enzymes?

A

Ferrochelatase

ALA Dehydratase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What accumulates in Lead Poisoning?

A

Protoporphyrin

D-ALA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What two steps in heme synthesis occur in mitochondria?

A

D-ALA Synthase (rate limiting)

Ferrochelatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Acute Intermittent Porphyria what enzyme defect?

A

Porphobilinogen Deaminase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What builds up in Acute Intermittent Porphyria?

A

Porphobilinogen

D-ALA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What builds up in urine in Acute Intermittent Porphyria?

A

Coporphobilinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Symptoms of AIP?

A 
Painful Abdomen
Port wine-colored urine (changes color)
Polyneuropathy
Psych disturbances
Precipitated by CYP inducers, alcohol, starvation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Treatment of AIP?

A

Glucose and Heme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Porphyria Cutanea Tarda enzyme defect?

A

Uroporphyrinogen Decarboxylase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What builds up in Porphyria Cutanea Tarda?

A

Uroporphyrin (tea-colored urine)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Symptoms of Porphyria Cutanea Tarda?

A

Blistering Cutaneous Photosensitivity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Sideroblastic Anemia (X-linked) what enzyme defect?

A

D-ALA Synthase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Glycine/Succinyl CoA -> D-ALA

A

D-ALA Synthase (requires B6)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

D-ALA -> Porphobilinogen

A

D-ALA Dehydratase (Pb Poisoning)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Porphobilinogen -> Hydroxymethylbilane

A

Porphobilinogen Deaminase (AIP)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Uroporphyrinogen III -> Coproporphyrinogen III

A

Uroporphyrinogen Decarboxylase (PCT)

17
Q

Protoporphyrin/Fe -> heme

A

Ferrochelatase (Pb Poisoning)

First Aid Heme-Onc Chapter (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions