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First Aid Heme-Onc Chapter > Antitumor Antibiotics > Flashcards

Antitumor Antibiotics Flashcards

1
Q

MoA of Bleomycin

A

induces free radical formation which breaks DNA strands

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2
Q

Use of Bleomycin

A

Testicular Cancer and Hodgkin Lymphoma

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3
Q

Tox of Bleomycin (3)

A

Pulmonary Fibrosis
Skin Hyperpigmentation
no Myelosuppression (compare to Busulfan)

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4
Q

MoA Dactinomycin (Actinomycin D)

A

Intercalates DNA

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5
Q

Use of Dactinomycin (ACTinomycin D)

A

childhood tumors (kids ACT out)
Wilms Tumor
Ewing Sarcoma
Rhabdomyosarcoma

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6
Q

Tox of Dactinomycin?

A

Myelosuppression

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7
Q

MoA of Doxorubicin and Daunorubicin

A

Generates Free Radicals

Intercalates DNA -> decreased replication

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8
Q

Use of Doxorobucin and Daunorubicin

A

Solid Tumors

Leukemias/Lymphomas

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9
Q

Tox of Doxorobucin and Daunorubicin

A

Dilated Cardiomyopathy
Myelosuppression
Alopecia

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10
Q

What can be used with Doxorobucin and Daunorubicin to prevent cardiotoxicity?

A

Dexrazoxaane (iron chelating agent)

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First Aid Heme-Onc Chapter (8 decks)

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