Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

First Aid Heme-Onc Chapter > Alkylating Agents > Flashcards

Alkylating Agents Flashcards

1
Q

MoA of Busulfan

A

Cross-links DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is used to ablate patient’s bone marrow before bone marrow transplantation?

A

Busulfan

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Use of Busulfan

A

CML

ablating bone marrow before BM transplant

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Tox of Busulfan

A

Severe Myelosuppression (in almost all cases)
Pulmonary Fibrosis
Hyperpigmentation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

MoA of Cyclophosphamide, Ifosfamide

A

Cross-links DNA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Where do Cyclophosphamide and Ifosfamide cross-link DNA at?

A

cross-links DNA at Guanine N-7

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What must happen to Cyclophosphamide and Ifosfamide before they work?

A

bioactivation in the liver

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Clinical Use Cyclophosphamide, Ifosfamide

A

solid tumors
leukemias/lymphomas
Vasculitides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Tox of Cyclophosphamide, Ifosfamide

A

Myelosuppression

Hemorrhagic Cystitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

How do you prevent Cyclophosphamide, Ifosfamide Hemorrhagic Cystitis?

A

Mesna

N-Acetylcysteine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

How does Mesna work?

A

Mesna prevents Cyclophosphamide induced Hemorrhagic Cystitis by a thiol group binding to toxic metabolites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the Nitrosureas? (4)

A

Carmustine
Lomustine
Semustine
Streptozocin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

MoA of Nitrosureas

A

cross-link DNA

crosses BBB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What must happen to Nitrosureas before they work?

A

Require Bioactivation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Use of Nitrosureas

A

Brain Tumors

Glioblastoma Multiforme

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tox of Nitrosureas

A

CNS Tox

Convulsions, Dizziness, Ataxia

First Aid Heme-Onc Chapter (8 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions