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Radiation Biology > Radioprotectors > Flashcards

Radioprotectors Flashcards

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1
Q

Dose Reduction Factor

A

Dose of radiation with the drug / Dose of radiation without the drug

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2
Q

Radioprotectors

A

Chemical compounds that provide protection against the effects of sparsely ionizing x-ray and gamma radiation through free-radically scavenging or hydrogen atom donation at sites of DNA damage

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3
Q

Effectiveness of radioprotectors vs. LET

A

Effectiveness decreases as LET increases

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4
Q

3 Prominent Radioprotection Compounds

A

WR-638 Cystaphos

WR-2721 Amifostine

WR-1607 d-CON (rat poison)

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5
Q

Amifostine

A

Only radioprotective drug approved by FDA for use in radiation therapy under the trade name Ethyol

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6
Q

Radioprotectors must be provided before/during/after exposure?

A

Before

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Radiation Biology (11 decks)

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