LET & RBE Flashcards

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1
Q

Linear Energy Transfer

A

Average energy deposited per unit track length (keV/um)

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2
Q

Low LET Radiations

A

X-Rays

Gamma Rays

High Energy Beta particles

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3
Q

High LET Radiations

A

Alpha particles

Low Energy Beta particles

Protons

Neutrons

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4
Q

LET vs. Energy for photons

A

LET tends to increase with photon energy until very high energies

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5
Q

Relative Biological Effectiveness

A

The ratio of the standard dose to the test dose required for equal biological effect.

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6
Q

RBE depends on…

A

Radiation Quality

Biological Endpoint

Biological System

Choice of radiation “standard”

Radiation dose and dose rate

Number of dose fractions

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7
Q

Relationship between RBE and LET

A

RBE increases with LET up to about 100 keV/um

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8
Q

Optimal LET

A

About 100 keV/um

Greatest RBE because the separation between ionizing events is approximately equal to the diameter of the DNA double helix, leading to the highest probability of double strand break per dose

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