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Pharma > RAAS > Flashcards

RAAS Flashcards

1
Q

Renin ⬆️ bei…

A

(Protease)
Sympathikus⬆️
Perfusionsdruck im Vas afferenz⬇️
[NaCl] im dist. Tubulus⬇️

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2
Q

Angiotensin ll Wirkungen

A 
Endothelzellen/Plasma             Stärkster Vasokonstriktor
Aldosteronfreisetzung
Vasokonstriktion
Nierendurchblutung⬇️
Na Resorption⬆️
H+ Sekretion⬆️
Myokardhypertrophie
ADH Freisetzung, Durst
⏹Reninfreisetzung
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3
Q

Renininhibitoren

A

⏹ die Protease

Aliskiren 🐈

Nur zur arteriellen Hypertonie zugelassen

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4
Q

Angiotensin-ll-Rezeptor-Antagonisten

A

üAT1-R.-Ant.=Sartane👹

Candesartan
Losartan
Valsartan 🐳👹

Bei ACE-H.Unverträglichkeit

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5
Q

ACE-Hemmer

A

Captopril
Enalapril*
Lisinopril
Ramipril*

*Prodrugs. !Angiotensin Escape Phänomen! Wirkung auch am Bradykinin»>⏹Bradykininabbau➡️ Reizhusten, Angioödem
Kardioprotektiv
[K+]⬆️

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6
Q

Bradykinin

A 
⬆️ Gefäßpermeabilität
Vasodilatation
⏹ Thrombozytenaggregation
⏹Remodeling
⬆️Nozizeption

Bei Entzündungsprozessen beteiligt

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7
Q

Nephrilysin

A

Spaltet Bradykinin und Natriuretische Peptide BNP, ANP

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8
Q

Nephrilysin-Inhibitor

A

Sacubitil 🎒🏏

Kombi mit SARTANEN&raquo_space;> ARNI (Angiotensin Rezeptor-Nephrolysin Inhibitor)

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Pharma (9 decks)

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