RAAS Flashcards
1
Q
Explain how hypotension activates the renin-angiotensin system.
A
Reduced perfusion pressure of the renal afferent arteriole stimulates renin release from the juxtaglomerular cells of the afferent arteriole.
2
Q
How does the RAAS contribute to the restoration of the blood volume?
A
Renin converts Angiotensinogen to Angiotensin I.
Angiotensin I is converted to Angiotensin II in the lungs by the Angiotensin-Converting-Enzyme
Angiotensin II causes arteriolar constriction, and increased blood pressure, as well as increased Aldosterone release, which causes increased sodium and water retention in the kidneys.
3
Q
What other factors increase renin secretion?
A
Stimulation of Beta-1-adrenoceptors (increased catecholamines, increased sympathetic activity)
