RAAS Flashcards
When does RAAS get activated?
Blood volume drops and bp drops
What is the purpose of RAAS?
Increase blood volume and bp
What is the order of RAAS?
Renin, angiotensin, aldosterone
How many nephrons per kidney?
1 million
Where are the nephrons in the kidney?
Cortex
Does the afferent arteriole bring blood in or out of glomerulus?
in
Does the efferent arteriole bring blood in or out of glomerulus?
out
How much blood and filtrate does the kidneys filter each minute?
120mL
How much filtrate is produced each day?
180 liters
How much do we pee each day?
1.8L
Where is renin released?
Afferent arteriole
Is renin a hormone or enzyme?
enzyme
What cells release renin (2 names)?
Juxtaglomerular cells or Granular cells
How do the cells know if blood vol has dropped?
baroreceptors
Which cells in descending convoluted tubule measure concentration of Na?
Macula densa cells
What are the 3 reasons Renin can be released?
1) Decrease BP in afferent arteriole
2) Decrease Na in DCT
3) Increased SNS innervation
What protein does the liver store?
Angiotensinogen
What does renin and Angiotensinogen make?
angiotensin 1
Where does Angiotensin Converting Enzyme come from?
lungs
What does ACE + angiotensin 1 make?
angiotensin 2
What does Angiotensin 2 do?
1) Generalized vasoconstrictor -> increases BP
2) Constricts efferent arteriole
3) release aldosterone
4) release ADH
What does aldosterone do?
1) increases Na reabsorption
2) increases Blood volume
3) increase BP
Where is aldosterone released?
Adrenal gland
What does antidiuretic hormone do?
1) increase water reabsorption
2) increased blood volume
3) increased BP
Where is Antidiuretic hormone released?
posterior pituitary gland
What happens when the efferent arteriole is constricted?
increased GFR
