R8 Flashcards
what cases do you STOP aspirin for?
intracranial nsgy, middle ear surgery, posterior eye, intramedullary spine, prostate
benefits of low molecular weight heparin over unfractionated heparin?
selective inhibition of Xa
this is helpful bc Xa has limited function outside of coagulation system whereas thrombin is involved in immune system and inflammatory pathways
BOTH bind AT3 which inhibits activated factor X and thrombin
aspirin inhibits platelet aggregation by blocking what?
thromboxane
Can you use NDMB with LE and MG?
yes!
but can only use DEPOLARIZING with LE. MG is resistant
what opiate does not cause increase in sphincter of oddi tone?
butorphanol
preferred opiate for biliary spasm therefore. more effective in women than in men.
mu agonist/antagonist with partial K agonism
the liver synthesizes most coagulation factors except for
3, 4, 8
8: endothelial cells and bone marrow
why is peak expiratory pressure decreased by up to 40% by epidurals?
because it is largely dependent on abdominal musculature
common complication of jet ventilation
hypercarbia
infrequently: necrotizing tracheobronchitis. PTX
treatment of AT3 deficiency?
AT3 replacement or ffp (1u per kg)
typical in patients with high dose heparization (heparin gtts)
lisinopril’s side effects
cough, angioedema, teratogen, increased creatinine, hypotension, hypercalemia,
how does METs play in with MACE?
if >4 METs, very rarely need further testing
why do kids get bradycardic with succs?
because they have high vagal tone which increases Ach muscarinic receptors. prevent with pre-admin of atropine
when does phase 2 block occur with succs?
ongoing infusion or doses > 4mg/kg
stays on receptor
only reliable muscle relaxant with IM admin?
succs – shot to the tongue best!
mechanism of tetanus?
inhibition of nt release from the inhibitory neurons in the CNS
