R7 Flashcards
codeine to morphine metabolite
P450 2D6
What metabolizes plavix into active drug?
P450 2C19
What metabolizes St. Johns Wort?
P450 3A4
treatment of saline-induced hyperchloremic non-AG acidosis?
crystalloid with high SID (sodium bicarb or Tham solution)
how to figure out drug concentration of LA?
move decimal over 1 to the right (eg: 2% lidocaine = 20 mg/ml)
LA potency is determined by
lipid solubility
most: bupi
least: procaine
LA onset of action is determined by
pKA
LA duration of action
protein binding
Acute resp alkalosis
pH increase of 0.1, HCO2- decrease of 2meq/l per 10meq of acutely decreased CO2
chi-squared test
NON-parametric, ordinal data, one to multiple sample tests
standard error formula
standard deviation / sqrt (number of samples)
type 1 error
null hypothesis INCORRECTLY rejected (saying there is a difference when there isn’t). called ALPHA, is false POSITIVES
more serious error
type II error
null hypothesis incorrectly ACCEPTED (saying no difference when there is). BETA
Power = 1-B
four ways to INCREASE power (also known as decreasing type 2 error)
- increase alpha
- decrease population variability
- increase sample size
- make difference between conditions greater
laryngospasm management
100% FiO2 with positive pressure <20, Larson maneuver, optional IV anesthetic (IV propofol 1mg/kg), last resort IV succs.
treatment of post-obsstructive pulmonary edema
PPV
when to consider ffp to reverse warfarin?
INR >1.5 in urgent/emergent cases
5-8ml/kg
remember FFP intrinsic INR 1.6-1.8
PCC is faster ($$). Vitamin K takes 24 hours
In a given system, the total pressure is equal to the sum of partial pressures of each component
Dalton Law
same thing with mixed gas tank pressures
Alveolar gas equation
PAO2 = (atm - Ph20) - PaCO2/R
R = 1.8 constant
With constant temperature, pressure and volume are inversely proportional
Boyle’s Law
If Pressure is held constant, volume and temperature will be directly proportional
Charles Law
If volume is kept the same, temperature and pressure of a gas are proportional
Gay-Lussac Law
MC cause of complete heart block is blockage of what artery
RCA -> PDA -> AV nodal artery
inferior wall ischemia -> don’t use venodilators!
what test do I use to compare two populations with respect to a single variable with continuous data?
unpaired t-test
