Quizzes 7-11 Flashcards
Phase 3 of an acute hemolytic transfusion reaction is characterized by
bradykinin and tissue factor contribute to systemic vascular collapse & DIC
the reason for a mixed-field agglutination at Coombs IAT is
Recipient antibody(ies) are bound to donor RBC
If [antibody] decreases below detectable levels in a previously transfused recipient who is then transfused again, which of the following may occur
Delayed hemolytic transfusion reaction
An allergic transfusion reaction is caused by
Histamine release from mast cells that have been sensitized by IgE
Identify the lab result(s) present in TACO (transfusion-associated circulatory overload):
Increased BNP (brain natriuretic peptide)
Non-febrile hemolytic transfusion reactions are most likely caused by donor
WBCs
What is the ABO group and Rh type of an individual with the following serologic reactions?
Anti-A = 4+
Anti-B = 4+
A1 cells = 0
B cells = 0
anti-D = 0
AB negative
The most likely cause of sepsis in a transfused patient is
bacterial contamination of the pRBC unit
A positive DAT with post-transfusion hemolysis in serum or plasma from a febrile patient suggests the diagnosis of
acute/delayed immune hemolytic reaction
Prevention of post-transfusion purpura can be achieved by
Using washed RBCs and antigen-negative platelets
Relative to other patient demographics, impaired cell-mediated immunity patients are at the highest risk for
TAGVHD (Transfusion-associated graft-versus-host disease)
Gamma irradiation of cellular products is used to help prevent:
TAGVHD
Which of the following can be used to prevent septic transfusion reactions:
Inspection of the pRBC units for discoloration, hemolysis, clots of the blood in the bag
Bacterial contamination of pRBCS can always be detected by QC/QA methods:
False
The most common gram negative pathogen causing septic transfusion reactions is:
Escherichia coli
The most common gram positive pathogen causing septic transfusion reactions is:
Coagulase-negative Staphylococci
Destruction of fetal and neonatal RBCs are by antibodies produced by the
Mother
Antibodies are directed against antigens on fetal and newborn RBCs inherited from the Fetus
Father
Identify the cell type that would not be observed in the peripheral blood of a healthy adult but may appear in erythroblastosis fetalis
Nucleated RBCs
Identify the parameter that indicates that you have fetal blood and not maternal blood from an umbilical vein specimen:
High MCV means you have fetal blood
The method of the Rosette Test (fetal-screen) for fetal-maternal hemorrhage involves
Counting rosettes formed by indicator RBCs that have attached to anti-D on maternal cells
Identify the test that quantifies the adequate amount of RhoGAM to be given
Kleihauer-Betke Test
What is the ABO group and Rh type of an individual with the following serologic reactions?
Anti-A = 4+
anti-B = 0
A cells = 0
B cells = 4+
anti-D = 3+
A positive
Identify the characteristics of Gel Card and solid phase methodologies as related to AIHA autoantibodies:
enhance the sensitivity of detection of autoantibody coated RBCs especially with IgG
Increased LDH and increased unconjugated bilirubin is measured in:
uncompensated anemia caused by an autoantibody
Haptoglobin is markedly decreased in:
uncompensated anemia caused by an autoantibody
Cold autoantibodies can be seen to cause which of the following observed in the correct area of a Wright-Giemsa stained peripheral smear:
RBC agglutination
The Doneth-Landsteiner test is used to test for
PCH (paroxysmal cold hemoglobinuria)
Panagglutination can be distinguished from alloantibodies by
Panagglutination will show agglutination 3+ - 4+ in all panel cells
Spherocytes may be observed in:
Warm AIHA (Autoimmune hemolytic anemia)
Which of the following will distinguish panagglutination from an alloantibody against a high frequency (prevalence) antigen using AHG
Panagglutination shows 3+ - 4+ with all panel cells including autocontrol
Identify the correct characteristic(s) of stored packed RBCs:
Stored 1-6 C with CPDA-1, shelf-life is 35 days
The hematocrit of packed RBCS stored with CPD or CPDA-1 is:
65-85%
Reducing the risk of the occurrence of febrile non-hemolytic reactions is to transfuse:
Leukoreduced packed RBCs
Reducing the risk of the repeated allergic reactions is to transfuse:
Washed packed RBCs
Storage requirements for thawed FFP are:
1-6 C for 24 hours
Identify the product that is used to replace decreased fibrinogen, FVIII, vWF, FXIII, and fibronectin:
Cryoprecipitate
Cryoprecipitate is primarily transfused for
Fibrinogen replacement
