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BMS 185 Lecture > Lecture 14 (on final) > Flashcards

Lecture 14 (on final) Flashcards

1
Q

Fresh Frozen Plasma (FFP) should be ____________ with the recipient

A

ABO compatible (ignore Rh)

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2
Q

What is the volume range of Fresh Frozen Plasma (FFP) transfused into a patient?

A

50-200mL

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3
Q

What is in Fresh Frozen Plasma (FFP)?

A

Factor VIII, Factor IX, Fibrinogen, Albumin, Globulin

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4
Q

What temperature do you store Fresh Frozen Plasma (FFP)?

A

-20C

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5
Q

What temperature do you keep thawed Fresh Frozen Plasma (FFP)?

A

4C (modern = 5 days; old af = 24 hrs)

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6
Q

When should plasma be frozen?

A

within 8 hrs of collection

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7
Q

What is oncotic pressure?

A

pressure that keeps water in the plasma

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8
Q

Fresh Frozen Plasma (FFP) is hyper____(3) and hypo____(1)

A
  1. hyperosmolal (pressure)
  2. hyperglycemic (glucose)
  3. hypernatremic (sodium)
  4. hypochloremic (chlorine)
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9
Q

What are Fresh Frozen Plasma (FFP) indications (people who would need it???)?

A
  1. single clotting factor deficiency
  2. multiple clotting factors deficiencies (DIC)
  3. massive transfusions
  4. warfarin overdose
  5. hemorrhagic disease of neonates
  6. TTP
  7. liver failure
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10
Q

What is cryoprecipitate?

A

a concentrate of cold and insoluble high-molecular-weight plasma proteins

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11
Q

What is the most common reason for use of cryoprecipitate?

A

fibrinogen replacement

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12
Q

What diseases are treated with cryoprecipitate?

A
  1. Fibrinogen replacement
  2. Factor VIII deficiency (Hemophilia A)
  3. von Willebrand’s Disease
  4. Congenital or acquired fibrinogen defects (dysfibrinogenemia)
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13
Q

How is cryoprecipitate made?

A

precipitates form when frozen plasma is slowly thawed at 1-6C

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14
Q

What blood clotting proteins does cryoprecipitate contain?

A
  1. Fibrinogen
  2. Factor VIII
  3. Facttor XIII
  4. Von Willebrand Factor (VWF)
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15
Q

Can cryoprecipitate be refrozen?

A

no

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16
Q

How long can you store thawed cryoprecipitate?

A

6 hrs

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17
Q

What is cryoprecipitate reduced? What does this treat?

A
  1. leftover plasma in cryoprecipitate
  2. used for treating Thrombotic thrombocytopenic purpura (TTP)
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18
Q

What is plasma 24?

A

plasma thawed within 24 hrs

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19
Q

Is plasma thawed past 5 days still theraputic?

A

yes, it just has less factor V and factor VIII

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20
Q

What deficiency is NOT treated with plasma?

A

Congenital Coagulation Factor Deficiency
(NEED A LOT or would cause volume overload if you used enough to be therapeutic)

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21
Q

What is a coagulation factor unit?

A

the (1 unit of coagulation factor) activity in 1 mL of pooled normal plasma; 1unit/mL or 100 units/dL

22
Q

How is cryoprecipitate made?

A

precipitates form when frozen plasma is slowly thawed at 1-6C

23
Q

What is the difference between Fresh Frozen Plasma (FFP) and cryoprecipitate, in terms of coagulation factors?

A
  1. Fresh Frozen Plasma (FFP) = all coag. factors
  2. cryoprecipitate = fibrinogen, factor VIII, factor XIII, and large von Willebrand factor (VWF)
24
Q

What is the difference between Fresh Frozen Plasma (FFP) and cryoprecipitate, in terms of volume?

A
  1. Fresh Frozen Plasma (FFP) = large volume
  2. cryoprecipitate = smaller volume
25
How much fibrinogen should be in each unit of cryoprecipitate?
at least 150mg of fibrinogen
26
What can be used as a fibrin sealent?
cryoprecipitate
27
How many units of factor VIII should be in each unit of cryoprecipitate?
80 units of factor VIII
28
How are derivatives different from blood components?
prepared by further manufacture of pooled, human source plasma, as well as from recombinant DNA technology (??? idk i think it just means further filtered to have an abundance of one specific factor???)
29
How are plasma-derived derivatives treated to destroy viruses in the unit?
1. heat 2. solvent detergent process
30
What does the solvent detergent process destroy (for virus-free derivatives)?
1. HIV 2. HBV 3. HCV
31
How are Activated Factor VII (VIIa) Derivatives produced?
recombinant DNA technology
32
What are Activated Factor VII (VIIa) Derivatives approved for (and not approved lol)?
1. Hemophilia w/ inhibition of Factor VIII or IX 2. congenital Factor VII deficiency with bleeding or prior to surgery (treatment) 3. Glanzmann’s thrombasthenia w/ absence or decreased response to platelet transfusions 4. (off-label/ NOT APPROVED) uncontrolled bleeding during surgery or from trauma
33
Factor VIII Concentrate Derivatives: 1. derived from... 2. treatment for...
1. Plasma derived 2. for treatment of hemophilia
34
What is Humate-P? What is it used for?
1. Factor VIII concentrate containing vWF 2. treatment of vWD hUMate-P = vWF (m = W) (P=F) humATE-p = factor *VIII*
35
What is Recombinant Factor VIII Derivatives used for?
prevent and treat bleeds in patients with hemophilia A
36
What is used to replace Factor VIII Concentrate Derivatives?
Recombinant Factor VIII Derivatives
37
What is used to replace Porcine Factor VIII Derivatives?
recombinant VIIa
38
What is Porcine Factor VIII Derivatives used for?
hemophiliacs with (factor VIII) inhibitors (people who bleed a lot b/c they do not have normal clotting factors)
39
Where is factor IX derivatives, derived from?
both plasma derived and recombinant formulation
40
Where is factor XIII derivatives, derived from?
recombinant-derived
41
What is fibrinogen derivatives?
plasma-derived
42
What is Fibrinogen derivatives used for?
congenital afibrinogenemia treatment
43
Where is Immune Serum Globulin Derivatives derived from?
1. Intravenous (IV) 2. Intramuscular (IM) formulations
44
What diseases use Immune Serum Globulin Derivatives as treatment?
1. Wiskott-Aldrich syndrome 2. SCIDs ( Severe Combined Immunodeficiency Disease) 3. Immune thrombocytopenia (ITP) Globulin = Old people = Wiskott Wiskott got SCID marks In TP
45
What types of albumin derivatives are available?
1. 5% 2. 25 %
46
What diseases/situations do you use albumin derivatives?
1. (liver disease) patients who are hypovolemic and hypoproteinemic 2. patients in shock 3. burn patients
47
What is Anti-Thrombotic Derivatives?
Anti-thrombin (AT) and protein C concentrates
48
Who would need Anti-Thrombotic Derivatives?
patients deficient in Anti-thrombin (AT) and/or protein C
49
What derivatives come from only Recombinant DNA technology?
1. Activated Factor VII (VIIa) 2. Recombinant Factor VIII 3. Factor XIII
50
What derivatives come from only plasma?
1. Factor VIII Concentrate 2. fibrinogen

BMS 185 Lecture (11 decks)

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