Quiz 7

Question 1

Which of the following changes is least likely to occur as a result of exogenous testosterone administration at dosages used for anabolic effect (i.e. "abusing steroids")?
Select one:
a. Acne
b. Increased muscle mass
c. Increased bone mass
d. Anemia
e. None of the above

Answer 1

Anemia

Question 2

A low serum testosterone with a low FSH and a low LH with an elevated GnRH is consistent with which of the following?
Select one:
a. 5-alpha-reductase deficiency
b. Primary hypogonadism
c. Cushing's syndrome
d. Secondary hypogonadism
e. Aromatase deficiency

Answer 2

Secondary hypogonadism (Correct–there is a pituitary dysfunction)

Question 3

Spermatogenesis occurs within the:
Select one:
a. Prostate
b. Epididymis
c. Leydig cells
d. Vas deferens
e. Seminiferous tubules

Answer 3

Seminiferous tubules

Question 4

What is the most common genetic cause of secondary hypogonadism (hypogonadotrophic hypogonadism) in males?
Select one:
a. GnRH insensitivity
b. Kallmann syndrome
c. Klinefelter syndrome
d. Down's syndrome
e. Fetal alcohol syndrome

Answer 4

Kallmann syndrome

Question 5

Which statement is true regarding Sertoli cells?
Select one:
a. Respond primarily to FSH
b. Found in the ovarian stroma
c. Secrete primarily androgens (mostly androstenedione)
d. Are lacking the enzyme aromatase
e. Found in the interstitial space between the seminiferous tubules

Answer 5

Respond primarily to FSH

Question 6

Which of the following routes of administration of testosterone carries the greatest risk of possible liver damage?
Select one:
a. I.M. injection
b. Topical gel
c. Transdermal patch
d. S.L. troche
e. P.O. tablets

Answer 6

P.O. tablets

Question 7

Which statement is not true regarding aromatase?
Select one:
a. Levels elevate with age in men
b. Aromatase inhibitors, such as anastrozole (Arimidex), may be used in the therapy of estrogen(+) breast cancers
c. Widely present in adipose tissue in both men & women
d. Is an intracellular cytochrome p450 (CYP450) enzyme
e. Responsible for converting estrogens into androgens

Answer 7

Responsible for converting estrogens into androgens

Question 8

5-alpha-reductase inhibitors, such as finasteride & dutasteride, are useful in the treatment of all of the following except:
Select one:
a. Benign prostatic hyperplasia
b. Androgenic alopecia
c. Prostate cancer
d. Erectile dysfunction
e. All of the above

Answer 8

Erectile dysfunction

Question 9

Which statement best describes the action of leuprolide acetate (Lupron)?
Select one:
a. Acts as a 5-alpha reductase inhibitor
b. Gynecomastia in males is a common adverse effect
c. Acts as an aromatase inhibitor
d. Interrupts the pulsatile rhythm of GnRH, leading to decreased FSH & LH
e. Prevents the sulfation of DHEA to DHEA-S

Answer 9

Interrupts the pulsatile rhythm of GnRH, leading to decreased FSH & LH

Question 10

Klinefelter's syndrome is associated with all of the following except:
Select one:
a. Reduced testicular volume
b. Accessory X chromosome (47 XXY)
c. GnRH insensitivity
d. Gynecomastia
e. Azoospermia

Answer 10

GnRH insensitivity