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OLD "MIC 660" > Quiz 7 > Flashcards

Quiz 7 Flashcards

1
Q

What are the light chain isotypes?

A

kappa
lambda

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2
Q

What are the heavy chain isotypes?

A

IgM, D, G, A, E

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3
Q

What is the Fc region of an antibody?

A

binds to other immune cells

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4
Q

What is the Fab region of an antibody?

A

antigen binding region

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5
Q

Different isotypes have different _____________

A

functions

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6
Q

Do surface BCR or secreted antibodies bind antigen and initiate signaling pathways that activate the B cell?

A

surface BCR

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7
Q

Do surface BCR or secreted antibodies bind pathogens and foreign antigens targeting the bound cells/antigens to other immune system components

A

secreted antibodies

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8
Q

What 3 things vary about the heavy chain in different isotypes?

A

number of constant regions
level of glycosylation
length of hinge region

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9
Q

What does the hinge region of the Fab region allow?

A

antibody flexibility to antigen binding

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10
Q

Dimeric IgA are held together by ________

A

J chain

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11
Q

What Ig protects break milk?

A

IgA

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12
Q

What Ig protects fetuses?

A

IgG

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13
Q

What Ig combats inhaled and ingested pathogens?

A

IgE

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14
Q

What Ig’s neutralize?

A

G
A
M

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15
Q

What Ig’s opsonization (phagocytose)?

A

G
A

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16
Q

What Ig’s complement activation?

A

G
A
M

17
Q

What Ig’s activate innate immune cells (Granulocyte activation)?

A

D
G
E

18
Q

What Ig’s protect internal tissues?

A

G
A
M

19
Q

What Ig activates NK cells?

A

IgG

20
Q

What is Omenn Syndomre?

A

Rag 1/2 doesn’t work

21
Q

What is ADA deficiency?

A

prevents cell proliferation
increased dATP

22
Q

What is X-linked agammaglobulinemia?

A

Btk genes send surivial signal for B cells

23
Q

What is Hyper-IgM syndrome?

A

CD40 mutation or IKK defect or AID defect preventing class switching and somatic hyper mutation

24
Q

What is selective IgA deficiency?

A

lack of IgA so mucosal surfaces are exposed

25
Q

What are 2 secondary B cell immunodeficiencies?

A

chronic alcohol decreases B cell numbers
B cell leukemia forces out healthy cells

26
Q

Type II hypersensitivity reactions are caused by Ig___ and Ig___

A

IgM
IgG

27
Q

What is Goodpasture Syndrome (II)?

A

destruction of the basement membranes of the kidneys and lungs

28
Q

What is Hashimoto disease (II)?

A

destruction of thyroid epithelial cells by ADCMC (NK cells)

29
Q

What is Myasthenia gravis (II)?

A

acetylcholine receptor is blocked

30
Q

What is Systemic Lupus Erythematosus (III)?

A

destruction of communicating cells causing tissue damage

31
Q

What is Rheumatoid arthritis (III)?

A

autoantibodies that recognize Fc region of IgG or IgM forming complex

32
Q

What is Multiple Sclerosis?

A

EBV and GliCAM I are mimiced

OLD "MIC 660" (10 decks)

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