Quiz 7 Flashcards
What are the light chain isotypes?
kappa
lambda
What are the heavy chain isotypes?
IgM, D, G, A, E
What is the Fc region of an antibody?
binds to other immune cells
What is the Fab region of an antibody?
antigen binding region
Different isotypes have different _____________
functions
Do surface BCR or secreted antibodies bind antigen and initiate signaling pathways that activate the B cell?
surface BCR
Do surface BCR or secreted antibodies bind pathogens and foreign antigens targeting the bound cells/antigens to other immune system components
secreted antibodies
What 3 things vary about the heavy chain in different isotypes?
number of constant regions
level of glycosylation
length of hinge region
What does the hinge region of the Fab region allow?
antibody flexibility to antigen binding
Dimeric IgA are held together by ________
J chain
What Ig protects break milk?
IgA
What Ig protects fetuses?
IgG
What Ig combats inhaled and ingested pathogens?
IgE
What Ig’s neutralize?
G
A
M
What Ig’s opsonization (phagocytose)?
G
A
What Ig’s complement activation?
G
A
M
What Ig’s activate innate immune cells (Granulocyte activation)?
D
G
E
What Ig’s protect internal tissues?
G
A
M
What Ig activates NK cells?
IgG
What is Omenn Syndomre?
Rag 1/2 doesn’t work
What is ADA deficiency?
prevents cell proliferation
increased dATP
What is X-linked agammaglobulinemia?
Btk genes send surivial signal for B cells
What is Hyper-IgM syndrome?
CD40 mutation or IKK defect or AID defect preventing class switching and somatic hyper mutation
What is selective IgA deficiency?
lack of IgA so mucosal surfaces are exposed
