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OLD "MIC 660" > Quiz 6 > Flashcards

Quiz 6 Flashcards

1
Q

__________ at the surface of B cells are secreted by plasma cells to recognize native antigens

A

antibodies (immunoglobulins)

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2
Q

What are the 3 types of B cell populations?

A
  1. B-1
  2. B-2 (follicular)
  3. marginal-zone B cells
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3
Q

Where do B-1 B cells reside?

A

body cavities

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4
Q

What is the primary job of B-1 B cells?

A

protect gut and lungs

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5
Q

Where are B-1 B cells generated?

A

fetal liver (self renewing)

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6
Q

Do B-1 B cells have diversity?

A

No; generated during fetal development and just self renew (limited VDJ and NO somatic hypermutation and class switching)

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7
Q

Are B-1 B cell’s antibodies specific or broad?

A

broad because they are the first line of defense for cavities (act like PRRs)

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8
Q

Do B-1 B cells require T helper for activation?

A

No (T cell independent)

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9
Q

What isotype do B-1 B cells usually produce?

A

IgM

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10
Q

Do B-1 B cells produce memory B cells?

A

No because they don’t do class switching or somatic hypermutation

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11
Q

Where do B-2 B cells reside?

A

most areas of the body

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12
Q

Where are B-2 B cells generated?

A

bone marrow

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13
Q

Are B-2 B cell’s antibodies specific or broad?

A

broad

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14
Q

Do B-2 B cells require T helper for activation?

A

Yes (T cell dependent)

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15
Q

What isotype does B-2 B cells produce?

A

any of them

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16
Q

Do B-2 B cells produce memory B cells?

A

yes

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17
Q

Where do marginal-zone B cells reside?

A

spleen

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18
Q

What is the purpose of marginal-zone B cells?

A

protect against blood borne pathogens

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19
Q

What isotype does marginal-zone B cells produce?

A

IgM (can do IgG)

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20
Q

Do B cells stay in primary tissues until development is complete?

A

No they leave and finish development in spleen where they can interact with T cells

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21
Q

What is the commitment signal for B cells?

A

IL-7

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22
Q

Bone marrow stromal cells express _______ and cells destined to become a B cell expresses ______

A

IL-7

IL-7R

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23
Q

What happens during Early Pro stage of B cell development?

A

heavy chain VDJ recombination
DJ join

24
Q

What happens during Late Pro stage of B cell development?

A

V joins DJ
checkpoint got productive heavy chain

25
Q

What happens during Pre-B stage of B cell development?

A

light chain VJ recombination
checkpoint for light chain

26
Q

What happens during immature B stage of B cell development?

A

negative selection
receptor editing
exit bone marrow for spleen

27
Q

What happens during T1 stage of B cell development?

A

negative selection
peripheral tolerance

28
Q

What happens during T2 stage of B cell development?

A

positive selection

29
Q

What does the B cells surrogate light chain contain that tests if the heavy chain works?

A

VpreB and gamma 5

30
Q

What does VpreB mimic?

A

variable region of the light chain

31
Q

What does gamma5 mimic?

A

constant region of the light chain

32
Q

During the heavy chain checkpoint, the heavy chain forms a complex with ____ and _____ to test for the ability to form the Pre-B cell receptor

A

Ig alpha
Ig beta

33
Q

What happens to a large pre-B cell?

A

allelic exclusion of heavy chain

34
Q

What happens to small pre-B cells?

A

light chain recombination

35
Q

What are the 2 loci of small pre-B cells?

A

kappa and lambda

36
Q

If one light chain loci of BCR cannot make a functional light chain what happens to the other light chain loci?

A

it gets a chance to rearrange

37
Q

If the heavy and light chain both successfully rearrange, what is the B cell called now?

A

immature B cell

38
Q

What are the stages of a B cell?

A
  1. early pro-B cell
  2. late pro-B cell
  3. large pre-B cell
  4. small pre-B cell
  5. immature B cell
39
Q

Immature B cells in the bone marrow that recognize self-antigen have three fates…

A
  1. clonal deletion (apoptosis)
  2. receptor editing (second try)
  3. anergy
40
Q

What are multivalent antigens?

A

molecules with more than one identical antigen receptor
results in cross linking of BCRs

41
Q

What are monovalent antigens?

A

molecules with a single antigen receptor
no cross linking of BCR

42
Q

Where does the first negative selection occur?

A

Bone marrow

43
Q

Is negative selection in B cells as strict as T cells?

A

No, they don’t have AIRE because they use other T cells instead

44
Q

What are B cells called that continue thier development in the spleen?

A

Transnational B cells

45
Q

What happens during transitional 1 B cells?

A

another round of negative selection

46
Q

What does T1 B cells express lower during negative selecgtion?

A

BAFF

47
Q

What happens during transitional 2 B cells?

A

another positive selection

48
Q

_____B cells need BAFF but ____B cells dont

A

B-2

B-1

49
Q

What do marginal B cells attack?

A

blood born pathogens

50
Q

What is the first step of B cell activation?

A

cross linking BCR that signals ITAM cascade

51
Q

What 3 things are B cell corecptors made of?

A

CR2
CD19
CD81

52
Q

In B cell activation, what is the signal that starts the 3 signaling pathways?

A

Syk

53
Q

Do T-2 independent B cells require a secondary signal?

A

no

54
Q

Do T-1 or T-2 independent B cells do excessive crosslinking of BCR?

A

TI-2

55
Q

What 2 signals does T dependent B cells require?

A

BCR-C3b
CD-40

OLD "MIC 660" (10 decks)

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