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Immunology and Serology MDLS 4169 > Quiz 6 > Flashcards

Quiz 6 Flashcards

1
Q

A 12-year-old girl presented to her physician with a sore throat, lymphadenopathy, and fatigue. Her laboratory results were 5,000 lymphocytes/microliter with 10% atypical lymphocytes, cytomegalovirus antibody negative, and heterophile antibody screen negative. These laboratory results:

A

suggest a diagnosis of infectious mononucleosis but should be followed by a test for IgM anti-VCA to strengthen the diagnosis.

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2
Q

A 14-year-old boy presents to the physician complaining of sore throat, fatigue, and fever for the past week. A monotest is performed and is reported as positive. It is likely that this boy has:

A

infectious mononucleosis.

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3
Q

A 17-year-old female with suspected mononucleosis tested negative for heterophile antibody using the slide agglutination monotest. Her serum was sent to a reference laboratory, and the following results were obtained: negative for IgM anti-VCA, positive for antibody to EA-D. What do these results suggest?

A

She is in the early stages of the disease.

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4
Q

A laboratory test that is used to confirm syphilis and detects specific treponemal antibodies is:

A

FTA-ABS.

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5
Q

A patient has an antibody profile for Epstein-Barr virus (EBV) performed, with the following results: EB-VCA IgM = pos; EB-VCA IgG = pos; EBV-EBNA = neg; EBV-EA-D = neg. This patient has which of the following?

A

Acute EBV infection

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6
Q

A patient has detectable levels of IgG and IgM against the viral capsid antigens of Epstein-Barr virus (EBV). This patient has:

A

a current infection with EBV.

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7
Q

A patient has fever, chills, muscle aches and headache. On his arms and legs, he has three skin lesions that looks like a red bullseye. Two weeks ago, he went on a hunting trip in the woods of Vermont, and he also traveled to Germany a month ago. The physician believes the patient has Lyme disease. A serum sample reacted positively in the ELISA, but the western blot was negative. What should be considered?

A

The patient is infected with a Borrelia sp. other than B. burgdorferi

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8
Q

A patient has the following Epstein-Barr virus (EBV) antibody profile: EB-VCA IgM = neg; EB-VCA IgG = pos; EBV-EA-R IgG = pos; EBV-EBNA IgG = pos. Which of the following is the correct interpretation of these data?

A

Reactivation of past infection with EBV

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9
Q

A patient is suspected of having latent syphilis. Which set of test results for RPR, TP-PA, and CSF-VDRL best confirms this diagnosis?

a. RPR = nonreactive; FTA-ABS = nonreactive; VDRL = nonreactive
b. RPR = nonreactive; FTA-ABS = reactive; VDRL = nonreactive
c. RPR = reactive 1:8; FTA-ABS = reactive; VDRL = reactive 1:4
d. RPR = reactive 1:2; FTA-ABS = nonreactive; VDRL = nonreactive

A

b. RPR = nonreactive; FTA-ABS = reactive; VDRL = nonreactive

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10
Q

A patient presents with a painless genital ulcer. The patient is then diagnosed as having syphilis. In what stage of syphilis is the patient?

A

Primary

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11
Q

A patient with infectious mononucleosis would have what outstanding feature in the hematology evaluation?

A

Presence of atypical lymphocytes

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12
Q

A physician suspects that his patient has infectious mononucleosis. Heterophile antibody tests are negative. Serological testing for Epstein-Barr virus (EBV) was performed, with the following results obtained: EBV VCA IgM = neg; EBV VCA IgG = neg; EBV-EA = neg; EBV-NA = neg. What is this person’s status with regard to EBV?

A

Never infected with EBV

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13
Q

A physician wants to know if his patient, who currently has a rash and fever, has an active rubeola virus infection. IgG against rubeola virus is detected. IgM against rubeola virus is not detected. What do these results mean?

A

The patient has had a previous exposure to measles, either through natural infection or vaccination.

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14
Q

A positive rubella titer in a healthy, nonpregnant 22-year-old female most likely indicates which of the following?

A

Immunity after administration of the vaccine

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15
Q

A primary disadvantage of using serology in the diagnosis of an infection is:

A

delayed appearance of antibodies after onset of infection.

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16
Q

A new technologist is busy one night and has to perform an RPR on a serum sample. He does not calibrate the needle delivering the antigen, and the needle is delivering a larger volume of antigen than it is supposed to. What kind of error can this produce?

A

Laboratory-induced false negative resulting from postzone

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17
Q

A newborn suspected of having a congenital viral infection should be tested for viral-specific antibody of which class(es)?

A

IgM

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18
Q

Acute glomerulonephritis can be a sequela of infection by:

A

Streptococcus pyogenes.

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19
Q

An antibody titer is defined as the reciprocal of the:

A

last serial dilution tube in which a positive reaction is still visible.

20
Q

If complement interferes with test results, the serum sample should be:

A

heated to 56°C for 30 minutes.

21
Q

In infectious mononucleosis, which of the following would be detectable earliest in the infection, thereby indicating a current infection?

A

Anti-VCA-IgM

22
Q

Laboratory results for a patient indicated a positive RPR and a negative FTA. The patient had no obvious sore, rash, or other symptoms. What is the most likely cause of these results?

A

Another disease, such as mononucleosis

23
Q

Patient serum is mixed with gel particles that have been sensitized with Treponema pallidum antigens as well as with unsensitized gel particles in a separate well. Agglutination was observed in the well with sensitized gel particles but not in the well with unsensitized gel particles. What is the interpretation of these results?

A

Positive for anti–T pallidum antibodies

24
Q

RPR stands for
a. reactive phosphate reagent.
b. Rapid plasma reagin.
c. reagin plasma reactive.
d. random positive reagin.

A

b. Rapid plasma reagin.

25
Q

Rubeola virus causes:

A

Measles

26
Q

Serology is performed on a patient with a rash and fever. Results are: rubella IgM = positive; rubella IgG = positive; measles IgM = negative; measles IgG = positive; varicella-zoster IgM = negative; varicella-zoster IgG = negative. What is the interpretation of these results?

A

Acute infection with rubella virus

27
Q

Swollen parotid glands are key diagnostic indicators of:

A

Mumps

28
Q

Tests for specific treponemal antibody include which of the following?

A

FTA-ABS

29
Q

The ability of an organism to cause disease is known as its:

A

pathogenicity

30
Q

The antibody called reagin that is found in syphilis reacts with…

A

cardiolipin

31
Q

The causative agent of infectious mononucleosis is:

A

Epstein-Barr virus.

32
Q

The pathogen that causes Lyme disease is

a. transmitted by ticks
b. a cause of syphilis
c. an obligate intracellular pathogen
d. transmitted by sexual activity

A

a. transmitted by ticks

33
Q

The pathogenesis of poststreptococcal glomerulonephritis involves:

A

deposition of immune complexes in the kidneys.

34
Q

The M protein of group A streptococci inhibits:

A

phagocytosis

35
Q

The RPR and VDRL are similar in which of the following ways?

a. Both are read macroscopically.
b. Both are flocculation reactions.
c. Both are specific assays for syphilis.
d. Both are antigen detection assays.

A

b. Both are flocculation reactions.

36
Q

The RPR and VDRL tests differ from each other in which of the following ways?

a. Specificity of antibody detected
b. Specificity of antigen detected
c. Method for reading or visualizing the reaction
d. Principle for detecting antigen–antibody complexes

A

c. Method for reading or visualizing the reaction

37
Q

What is the most common routine diagnostic test for rubella virus infection in a young adult?

A

Antibody detection

38
Q

Which of the following illnesses is not caused by Streptococcus pyogenes directly, but rather by destructive host defense responses?

a. Scarlet fever
b. Pharyngitis
c. Acute rheumatic fever
d. Pyoderma (impetigo)

A

c. Acute rheumatic fever

39
Q

Which of the following is a cause of a laboratory-induced false-negative result in the screening tests for syphilis?
a. Systemic lupus erythematosus
b. Alcohol ingestion prior to blood draw
c. Excess serum antibody
d. Temperature greater than 30°C

A

c. Excess serum antibody

40
Q

Which of the following is the first reaction in a lateral flow immunochromatographic assay?

a. Antibody reacts with a labeled antigen.
b. Antigen is captured by antibody immobilized at a specific location on a membrane.
c. Antigen reacts with a labeled antibody.
d. Labeled antibody is captured by membrane-immobilized antibody.

A

c. Antigen reacts with a labeled antibody.

41
Q

Which of the following markers is a reliable indicator of high infectivity and active disease?

a. HBeAg
b. anti-HBcAg IgG
c. HBcAg
d. HBsAg

A

a. HBeAg

42
Q

42.) Which of the following positive antibody tests may be an indication of recent rubella vaccination or early primary rubella infection in a patient with no clinical symptoms?
a. Only IgG positive
b. Both IgG and IgA antibodies positive
c. Only IgM positive
d. Fourfold rise in titer for IgG

A

c. Only IgM positive

43
Q

Which of the following statements best describes how lateral flow assays demonstrate the presence of bacterial, fungal, and viral antigens?

a. Migration of labeled antigen to the capture zone produces a positive result.
b. During the assay, bacterial antigens present in a specimen are pretreated by coating them with colloidal gold prior to binding to an antibody.
c. A positive test results from the binding of the conjugated antibody and antigen to a fixed antibody directed against the antigen in the capture zone.
d. A positive test results from the precipitation of the antigen–antibody complex in the capture zone.

A

c. A positive test results from the binding of the conjugated antibody and antigen to a fixed antibody directed against the antigen in the capture zone.

44
Q

Which types of hepatitis are transmitted primarily through fecal-oral route?

A

Hepatitis A and E

45
Q

Which virus is transmitted primarily by aerosolized respiratory droplets?
a. Epstein-Barr virus
b. Hepatitis E
c. Varicella-zoster virus
d. Human T-cell lymphotropic virus type I

A

c. Varicella-zoster virus

Immunology and Serology MDLS 4169 (12 decks)

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