Quiz 4

Question 1

Plasma cell cancer common classified as a bone cancer

Answer 1

multiple myeloma

pg 101

Question 2

Population effected by multiple myeloma

Answer 2

elderly, males, African descent

pg 101

Question 3

Features of multiple myeloma

Answer 3

osteolytic lesions (bone pain, fracture, infection, anemia, hypercalcemia, metastatic Ca++), neurologicals (HA, dizziness, tinnitus, confusion), renal failure (Bence-Jones proteins, myeloma nephrosis)
pg 101

Question 4

Protein electrophoresis finding indicative of multiple myeloma

Answer 4

M-spike

pg 102

Question 5

Prognosis of multiple myeloma

Answer 5

poor, 4-6 years, incurable, progressive

pg 102

Question 6

Treatments for multiple myeloma

Answer 6

plasmapheresis, stem cell transplants(risky)

pg 102

Question 7

MC sites of lytic lesions in those with multiple myeloma

Answer 7

vertebral column 66%
ribs 44%
skull 41%
pelvis 28%
femur 24%
clavicle 10%
scapula 10%
pg 104

Question 8

The osteolytic lesions in multiple myeloma are characteristically described as…

Answer 8

“punch-out” lesions

pg 101 + 106

Question 9

Cancer of B cells arising from a SINGLE node, following a predictable pattern, and microscopic finding of Reed-Sternberg cells

Answer 9

Hodgkin lymphoma

pg 108

Question 10

“Owl-eye” nuclear appearance associated with Hodgkin lymphoma

Answer 10

Reed-Sternberg cells

pg 108

Question 11

Risks for Hodgkin lymphoma

Answer 11

male, 15-40 (>55), family history, EBV infection, agent orange, immunosuppression
pg 109

Question 12

Features of Hodgkin lymphoma

Answer 12

PAINLESS lymphadenopathy, single node, fever, night sweats, cachexia, anemia, splenomegaly, hepatomegaly, pruritis
pg 110

Question 13

Stage 1 Hodgkin lymphoma

Answer 13

single lymph node region involvement

pg 112

Question 14

Stage 2 Hodgkin lymphoma

Answer 14

two or more lymph node region involvement of the SAME side of the diaphragm
pg 112

Question 15

Stage 3 Hodgkin lymphoma

Answer 15

involvement of lymph node regions on BOTH sides of the diaphragm
pg 112

Question 16

Stage 4 Hodgkin lymphoma

Answer 16

multiple or disseminated foci of involvement of one or more extralymphatic organs
pg 112

Question 17

Treatment of Hodgkin lymphoma

Answer 17

chemotherapy, possible radiation
favorable prognosis
pg 113

Question 18

Transformed myeloblasts causes clonal proliferations replacing marrow

Answer 18

myeloid neoplasms

pg 116

Question 19

Categories of myeloid neoplasms

Answer 19

1) acute myelogenous leukemia
2) myelodysplastic syndromes
3) chronic myeloproliferative disorders
pg 116

Question 20

Aggressive cancer or myeloblasts

Answer 20

acute myeloid leukemia

pg 117

Question 21

Results of immature myeloblasts in marrow associated with acute myeloid leukemia

Answer 21

halted myeloid cell differentiation, displace marrow, suppresses hematopoiesis, may mimic feature of ALL
pg 117

Question 22

Microscopic finding associated with acute myeloid leukemia

Answer 22

auer rods

pg 117

Question 23

Acute myeloid leukemia most commonly presents with…

Answer 23

pancytopenia
(fatigue, fever, abnormal bleeding, bone pain, cachexia)
pg 118

Question 24

Treatment of acute myeloid leukemia

Answer 24

chemotherapy, bone marrow/stem cell transplant, transfusions

pg 118

Question 25

Prognosis of acute myeloid leukemia

Answer 25

poor, 15-30% long-term survival

pg 118

Question 26

What worsens the prognosis of acute myeloid leukemia

Answer 26

history myelodysplastic syndromes

pg 118