Quinolones Flashcards
1
Q
Quinolone Mechanism of Action
A
- Promote cleavage of bacterial DNA
- Inhibit DNA gyrase
2
Q
3 Major Quinolones
A
- Ciprofloxacin
- Levofloxacin
- Moxifloxacin
3
Q
Quinolone + Theophylline
A
Decrease in the metabolism, causing increased serum levels
*Not seen with levofloxacin
4
Q
Quinolone + Antacids
A
Not good, quinolones will not be absorbed
5
Q
Quinolone + Warfarin
A
Not good, increase anticoagulatory effects
6
Q
Ciprofloxacin: Spectrum of Activity
A
-Gram - (including SPACE)
7
Q
Levofloxacin and Moxifloxacin: Spectrum of Activity
A
- Gram +
- Gram - (including SPACE)
- Atypicals
8
Q
Which quinolone is most potent against gram - organisms
A
Ciprofloxacin
9
Q
Which quinolone can be used to combat anaerobes
A
Moxifloxacin
10
Q
Which quinolone can and which cant you use for UTI’s
A
Cant: Moxi
Can: Cipro and levo
