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POD Exam #2 > Cephalosporins > Flashcards

Cephalosporins Flashcards

1
Q

Cephalosporin family Mechanism of Action

A
  • Mimic D-ala-D-ala

- Inhibit cell wall synthesis by inhibiting peptidoglycan cross-linking

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2
Q

1st generation oral cephalosporin

A

Cephalexin

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3
Q

2nd generation oral cephalosporin

A

Cefuroxime Axetil

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4
Q

1st generation IV cephalosporin

A

Cefazolin

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5
Q

What drug is commonly used for surgical prophylaxis

A

Cefazolin

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6
Q

2nd generation IV cephalosporin (no anaerobic coverage)

A

Cefuroxime

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7
Q

2nd generation IV cephalosporin (anaerobic coverage)

A

Cefoxitin

Cefotetan

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8
Q

3rd generation IV cephalosporin (no pseudomonas coverage)

A

Ceftriaxone

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9
Q

3rd generation IV cephalosporin (pseudomonas coverage)

A

Ceftazidime

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10
Q

4th generation IV cephalosporin

A

Cefepime

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11
Q

5th generation IV cephalosporin

A

Ceftaroline

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12
Q

What are the 2 cephalosporins that cover MRSA

A

Cefepime

Ceftaroline

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13
Q

1st generation: Spectrum of activity

A
  • Staph

- Strep

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14
Q

2nd generation: Spectrum of activity

A
  • Staph
  • Strep
  • PEK
  • Anaerobes (cephamycins)
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15
Q

3rd generation: Spectrum of activity

A
  • Staph
  • Strep
  • PEK
  • SPACE
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16
Q

4th generation: Spectrum of activity

A
  • Staph
  • Strep
  • PEK
  • SPACE
17
Q

5th generation: Spectrum of activity

A
  • Staph
  • Strep
  • PEK
  • SCE (no pseudomonas or acinetobacter)
18
Q

T/F Cephalosporins generally do NOT cover enterococcus or atypicals

A

True

19
Q

What drug is commonly used for GI/abdominal surgery prophylaxis

A

Cephaymycins (Cefoxitan and Cefotetan)

20
Q

Whats the 3 big deal with cephalosporins that have an NMTT side chain

A
  • Increased bleeding risk (blocks clotting down the vitamin K pathway)
  • Disulfiram intolerence when combined with alcohol (makes patient violently ill)
  • Serum sickness-like intolerance in children

POD Exam #2 (9 decks)

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