Aminoglycosides Flashcards

1
Q

Aminoglycoside Mechanism of Action

A
  • Bind to outer membrane of cell, results in LPS rearrangement
  • Enters cell to bind 30S/50S ribosomal complex
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2
Q

T/F this drug has a PAE (post-antibiotic effect) and therefore utilizes concentration dependent killing

A

True

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3
Q

4 most common Aminoglycosides

A
  • Gentamicin
  • Neomycin
  • Amikacin
  • Tobramycin
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4
Q

Aminoglycoside: Spectrum of Activity

A

Gram - (up to SPACE)

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5
Q

For what organisms can an aminoglycoside be administered to produce a “synergistic effect,” what drug is it paired with

A
  • Gram +

- Paired with a beta-lactam

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6
Q

Aminoglycoside, CNS penetration

A

Poor, even with inflammation. Only exception is neonates (possibly due to immature BBB)

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7
Q

Aminoglycoside, Lung penetration

A

Poor

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8
Q

2 major adverse effects from amino glycoside usage

A
  • Ototoxicity (too high peaks)

- Nephrotoxicity (too high troughs)

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9
Q

Explain the complication with aminoglycoside usage while on neuromuscular blockade. What is treatment

A
  • Possible prolonged paralysis

- Administer 2g Calcium to the patient

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10
Q

What drug is commonly used to suppress intestinal flora for colorectal surgery

A

Neomycin

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11
Q

What drug is commonly used to clean operating room instruments

A

Gentamycin

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12
Q

T/F this drug has a topical administration that can be used to treat eye, ear, and skin infections

A

True

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13
Q

Why should patients receiving aminoglycoside therapy be monitored with lab testing

A

Narrow therapeutic index with adverse complications (ototoxicity, nephrotoxicity)

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