Carbapenems

Question 1

4 drugs that belong to the Carbapenem family

Answer 1

• Imipenem
• Meropenem
• Doripenem
• Ertapenem

Question 2

Carbapenem Mechanism of Action

Answer 2

Binds to PBP, inhibiting peptidoglycan cross-linking

Question 3

Carbapenem that is extensively metabolized by the renal system, also name of drug that can be given to keep in blood stream longer

Answer 3

• Imipenem

- Cilastatin keeps drug in serum

Question 4

What carbapenem is associated with seizures and how is this prevented

Answer 4

Imipenem

*Do not give to epileptic patients and adjust dose according to renal function

Question 5

Under what circumstance would you use a carbapenem rather than a penicillin (no penicillin allergy)

Answer 5

When dealing with an extended spectrum beta-lactamase bacteria

Question 6

What carbapenem is appropriate for the treatment of meningitis

Answer 6

Meropenem (no seizure side effect)

Question 7

Imipenem, Meropenem, Doripenem: Spectrum of Activity

Answer 7

• Gram +
• SPACE
• Anaerobes

Question 8

Ertapenem: Spectrum of Activity

Answer 8

• Gram +
• FENCE
• Anaerobes
• No enterococcus

Question 9

Which carbapenem can be used for once daily dosing, especially good for home health patients administering medication to themselves

Answer 9

Ertapenem

Question 10

T/F Carbapenems are still the drug of choice in treating ESBL organisms (generally PEK bugs)

Answer 10

True