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1 STEP UW Nephrology > Quick nephrotic > Flashcards

Quick nephrotic Flashcards

1
Q

Immune dysregulation due to/immunologic reaction?

A

Minimal change disease

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2
Q

immunizations?

A

Minimal change disease

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3
Q

child had viral infection?

A

Minimal change disease

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4
Q

atopic disorders (immunologic reaction to pollen/dust, insect stings)?

A

Minimal change disease

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5
Q

drugs (eg, NSAIDs)?

A

Minimal change disease

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6
Q

malignancy (eg, Hodgking LYMPHOMA)?

A

Minimal change disease

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7
Q

Il-13 cytokine?

A

Minimal change disease

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8
Q

Cell mediated injury to podocytes; production of glomerular permeability factor (IL-13)?

A

Minimal change disease

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9
Q

Is commonly associated with drug use (eg, heroin)?

A

Focal segmental glomerulosclerosis (FSGS)

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10
Q

viruses (eg, HIV)?

A

Focal segmental glomerulosclerosis (FSGS)

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11
Q

severe/massive obesity?

A

Focal segmental glomerulosclerosis (FSGS)

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12
Q

direct (eg, cytotoxic drugs) podocyte injury?

A

Focal segmental glomerulosclerosis (FSGS)

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13
Q

indirect (eg, glomerular hyperfiltration) podocyte injury?

A

Focal segmental glomerulosclerosis (FSGS)

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14
Q

Deposits may be of IgM, C1 and C3?

A

Focal segmental glomerulosclerosis (FSGS)

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15
Q

interferon treatment?

A

Focal segmental glomerulosclerosis (FSGS)

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16
Q

congenital malformation?

A

Focal segmental glomerulosclerosis (FSGS)

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17
Q

dense immune (IgG and C3) deposits?

A

Membranous nephropathy

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18
Q

Anti-phospholipase A2 receptor antibodies (anti-PLA2R antibodies)?

A

Membranous nephropathy

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19
Q

Chronic infection (eg, viral hepatitis (HBV, HCV), syphilis)?

A

Membranous nephropathy

20
Q

solid tumors (eg, lung, breast, prostate, colon)? especially suspect in elderly > 60yo

A

Membranous nephropathy

21
Q

drugs: NSAIDs, penicillamine, gold)?

A

Membranous nephropathy

22
Q

systemic lupus erythematous (SLE)?

A

Membranous nephropathy

23
Q

What progress to CKD?

A

Focal segmental glomerulosclerosis (FSGS)

Membranous nephropathy

24
Q

Amyloid depositions (AL amyloid, AA amyloid)?

A

Amyloidosis

25
Q

Most common cause of ESRD?

A

Diabetic glomerulonephropathy

26
Q

GBM thickening?

A

Diabetic glomerulonephropathy

27
Q

Increased mesangial matrix deposition (expansion)?

A

Diabetic glomerulonephropathy

28
Q

Kimmelstiel-Wilson nodules (glomerulosclerosis)?

A

Diabetic glomerulonephropathy

29
Q

diffuse thickening of the GBM without an increase in glomerular cellularity (hypercellularity)?

A

Membranous nephropathy

30
Q

irregular, electron-dense immune (IgG and C3) deposits?

A

Membranous nephropathy

31
Q

SUBEPITHELIAL DEPOSITS?

A

Membranous nephropathy

32
Q

spikes and domes?

A

Membranous nephropathy

33
Q

IF: granular deposits of IgG and C3 along the GBM?

A

Membranous nephropathy

34
Q

Most common cause of nephrotic syndrome in adults?

A

Membranous nephropathy

35
Q

sclerotic foci within the glomerulus (segmental sclerosis and hyalinosis)?

A

Focal segmental glomerulosclerosis (FSGS)

36
Q

diffuse podocyte foot process effacement similar as seen in minimal change disease?

A

Focal segmental glomerulosclerosis (FSGS)

37
Q

immune deposits (if present) typically occur in the sclerotic region of the glomerulus, not along the GBM. Deposits may be of IgM, C1 and C3?

A

Focal segmental glomerulosclerosis (FSGS)

38
Q

Selective proteinuria?

A

Minimal change disease

39
Q

Nonselective proteinuria?

A

other forms of nephrotic syndrome (eg, membranous nephropathy, focal segmental glomerulosclerosis).

40
Q

LM – normal glomeruli?

A

Minimal change disease

41
Q

EM – diffuse effacement and fusion of podocyte foot process?

A

Minimal change disease

42
Q

lipids in PCT?

A

Minimal change disease

43
Q

sickle cells disease?

A

Focal segmental glomerulosclerosis (FSGS)

44
Q

Anabolic steroids?

A

Focal segmental glomerulosclerosis (FSGS)

45
Q

interferon alpha?

A

Focal segmental glomerulosclerosis (FSGS)

1 STEP UW Nephrology (14 decks)

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