Quick nephrotic

Question 1

Immune dysregulation due to/immunologic reaction?

Answer 1

Minimal change disease

Question 2

immunizations?

Answer 2

Minimal change disease

Question 3

child had viral infection?

Answer 3

Minimal change disease

Question 4

atopic disorders (immunologic reaction to pollen/dust, insect stings)?

Answer 4

Minimal change disease

Question 5

drugs (eg, NSAIDs)?

Answer 5

Minimal change disease

Question 6

malignancy (eg, Hodgking LYMPHOMA)?

Answer 6

Minimal change disease

Question 7

Il-13 cytokine?

Answer 7

Minimal change disease

Question 8

Cell mediated injury to podocytes; production of glomerular permeability factor (IL-13)?

Answer 8

Minimal change disease

Question 9

Is commonly associated with drug use (eg, heroin)?

Answer 9

Focal segmental glomerulosclerosis (FSGS)

Question 10

viruses (eg, HIV)?

Answer 10

Focal segmental glomerulosclerosis (FSGS)

Question 11

severe/massive obesity?

Answer 11

Focal segmental glomerulosclerosis (FSGS)

Question 12

direct (eg, cytotoxic drugs) podocyte injury?

Answer 12

Focal segmental glomerulosclerosis (FSGS)

Question 13

indirect (eg, glomerular hyperfiltration) podocyte injury?

Answer 13

Focal segmental glomerulosclerosis (FSGS)

Question 14

Deposits may be of IgM, C1 and C3?

Answer 14

Focal segmental glomerulosclerosis (FSGS)

Question 15

interferon treatment?

Answer 15

Focal segmental glomerulosclerosis (FSGS)

Question 16

congenital malformation?

Answer 16

Focal segmental glomerulosclerosis (FSGS)

Question 17

dense immune (IgG and C3) deposits?

Answer 17

Membranous nephropathy

Question 18

Anti-phospholipase A2 receptor antibodies (anti-PLA2R antibodies)?

Answer 18

Membranous nephropathy

Question 19

Chronic infection (eg, viral hepatitis (HBV, HCV), syphilis)?

Answer 19

Membranous nephropathy

Question 20

solid tumors (eg, lung, breast, prostate, colon)? especially suspect in elderly > 60yo

Answer 20

Membranous nephropathy

Question 21

drugs: NSAIDs, penicillamine, gold)?

Answer 21

Membranous nephropathy

Question 22

systemic lupus erythematous (SLE)?

Answer 22

Membranous nephropathy

Question 23

What progress to CKD?

Answer 23

Focal segmental glomerulosclerosis (FSGS)

Membranous nephropathy

Question 24

Amyloid depositions (AL amyloid, AA amyloid)?

Answer 24

Amyloidosis

Question 25

Most common cause of ESRD?

Answer 25

Diabetic glomerulonephropathy

Question 26

GBM thickening?

Answer 26

Diabetic glomerulonephropathy

Question 27

Increased mesangial matrix deposition (expansion)?

Answer 27

Diabetic glomerulonephropathy

Question 28

Kimmelstiel-Wilson nodules (glomerulosclerosis)?

Answer 28

Diabetic glomerulonephropathy

Question 29

diffuse thickening of the GBM without an increase in glomerular cellularity (hypercellularity)?

Answer 29

Membranous nephropathy

Question 30

irregular, electron-dense immune (IgG and C3) deposits?

Answer 30

Membranous nephropathy

Question 31

SUBEPITHELIAL DEPOSITS?

Answer 31

Membranous nephropathy

Question 32

spikes and domes?

Answer 32

Membranous nephropathy

Question 33

IF: granular deposits of IgG and C3 along the GBM?

Answer 33

Membranous nephropathy

Question 34

Most common cause of nephrotic syndrome in adults?

Answer 34

Membranous nephropathy

Question 35

sclerotic foci within the glomerulus (segmental sclerosis and hyalinosis)?

Answer 35

Focal segmental glomerulosclerosis (FSGS)

Question 36

diffuse podocyte foot process effacement similar as seen in minimal change disease?

Answer 36

Focal segmental glomerulosclerosis (FSGS)

Question 37

immune deposits (if present) typically occur in the sclerotic region of the glomerulus, not along the GBM. Deposits may be of IgM, C1 and C3?

Answer 37

Focal segmental glomerulosclerosis (FSGS)

Question 38

Selective proteinuria?

Answer 38

Minimal change disease

Question 39

Nonselective proteinuria?

Answer 39

other forms of nephrotic syndrome (eg, membranous nephropathy, focal segmental glomerulosclerosis).

Question 40

LM – normal glomeruli?

Answer 40

Minimal change disease

Question 41

EM – diffuse effacement and fusion of podocyte foot process?

Answer 41

Minimal change disease

Question 42

lipids in PCT?

Answer 42

Minimal change disease

Question 43

sickle cells disease?

Answer 43

Focal segmental glomerulosclerosis (FSGS)

Question 44

Anabolic steroids?

Answer 44

Focal segmental glomerulosclerosis (FSGS)

Question 45

interferon alpha?

Answer 45

Focal segmental glomerulosclerosis (FSGS)