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1 STEP UW Nephrology > Aldosteronas (UW) > Flashcards

Aldosteronas (UW) Flashcards

1
Q

What type substance is aldosterone?

A

mineralcorticoid hormone

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2
Q

site of aldosterone production?

A

zona glomerulora in adrenal cortex

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3
Q

What pressure changes activate a release of aldosterone?

A

decr. blood pressure and decr. renal blood flow.

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4
Q

decr. blood pressure and decr. renal blood flow. Release of aldosterone. What is activated then?

A

ATII

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5
Q

What other conditions can increase release of aldosterone?

A

High serum potassium and increased ACTH levels (transient effect)

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6
Q

Mechanism of aldosterone?

A

increases number of basolateral Na/K ATPase pumps and apical Na channels in principal cells in cortical collecting ducts

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7
Q

Site of action of aldosterone?

A

Principal cells in cortical collecting ducts

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8
Q

Effect of aldosterone?

A

incr. Na and H20 reabsorption

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9
Q

due to aldosterone incr. Na and H20 reabsorption. What effect on K and H?

A

promotes K and H secretion

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10
Q

What cells secrete K?

A

principal

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11
Q

What cells secrete H?

A

intercalated

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12
Q

Aldosterone receptor antagonist effect on K and H?

A

Decrease secretion by collecting tubules

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13
Q

What does vasopresin on urea?

A

increase number of cell surface urea transporters in medullary collecting tubules . Results in increased urea reabsorption

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14
Q

Aldosterone secreting tumor. What disease?

A

Primary hyperaldosteronism (Conn’s syndrome)

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15
Q

Conn’s syndrome presentation?

A

Hypertension, hypokalemia, metabolic alkalosis (in collecting tubules loss of H), decreased RAAS activity.

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16
Q

treatment of unilateral adenoma?

A

surgical resection or medical therapy with aldosterone antagonists.

17
Q

The most common agent (first-line) used for the treatment of unilateral adenoma?

A

spironolactone

18
Q

If spironolactone is not tolerated what to use?

A

eplerenone (new agent for adenoma)

19
Q

What type of acidosis cause HYPOaldosteronism?

A

Type IV renal tubular acidosis

1 STEP UW Nephrology (14 decks)

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