Questions - Genomics

Question 1

All viruses contain either DNA or RNA as the genetic material, what is the exception?

Answer 1

Cytomegalovirus, traditionally a double stranded DNA virus but has also RNA strands

Question 2

All viruses are haploid, what is the exception?

Answer 2

retroviruses (diploid)

Question 3

DNA virus proteins enter the nucleus to replicate, what is the exception?

Answer 3

POX Virus

Question 4

RNA viruses proteins remain in the cytoplasm to replicate, what is the exception?

Answer 4

Retroviruses

Question 5

What is the genetic mechanism that could create an antigenic shift in influenza virus?

Answer 5

Reassortment (a mixing and matching of segments)

Question 6

Do RNA viruses accumulate more mutations than DNA viruses?

Answer 6

Yes. Why? No proofreading

Question 7

In replication there are 2 kinds of RNA polymerases: RNA dependent RNA polymerase and RNA dependent DNA Polymerase. What is another name for RNA dependent DNA polymerase?

Answer 7

Reverse transcriptase.

Question 8

Which type of virus hits the ground running?

Answer 8

Plus stranded RNA

Question 9

Which is the only DNA virus that has single stranded DNA?

Answer 9

Parvovirus B19

Question 10

What genomic material do herpes viruses have?

Answer 10

Double stranded DNA

Question 11

Exception to the rule of plus single stranded RNA virus is going to be directly made into mRNA?

Answer 11

HIV. There are two copies of the plus single stranded RNA (Diploid)

Question 12

Segmented genomes can engage in what type of genetic interaction?

Answer 12

Reassortment

Question 13

What genetic mechanisms can segmented viruses engage in that gives them a big jump in genetic composition?

Answer 13

Reassortment

Question 14

Which influenza virus shows antigenic shift (major genetic composition changes)?

Answer 14

Influenza A (because it affects many animal species)

Question 15

What is another name for recombination?

Answer 15

Copy choice

Question 16

Which types of viruses does recombination take place in?

Answer 16

RNA viruses only

Question 17

What are the 6 steps in the life cycle of an animal virus?

Answer 17

Adsorption
Penetration
Uncoating
Synthesis
Assembly
Release from the host cell

Question 18

What is tropism?

Answer 18

The affinity of a virus for a particular cell type (i.e. tropism for hepatocytes)

Question 19

Which is the smallest human DNA virus?

Answer 19

Parvovirus B-19

Question 20

Which is the only single stranded Arbovirus?

Answer 20

La Crosse Encephalitis (also only segmented one)

Question 21

Which virus shows antigenic shift (reassortment) and antigenic drift (regular, seasonal epidemics)?

Answer 21

Influenza Virus (shift only in Influenza A)

Question 22

Which viruses have a segmented genome?

Answer 22

LA-LA CO INFected HANa and ROTA

La Crosse
Lassa Fever
Coltivirus
Influenza
Hantavirus
Rotavirus