Questions - Drugs Flashcards
Can we use antibiotics on viruses?
No
Do we have a cure for latent viruses?
No
Who needs suppressive treatment?
Immunocompromised people
Which antivirals target viral thymidine kinase?
Acyclovir
Valacyclovir
Famciclovir
Which antivirals target cellular kinases?
Cidofovir
Which antivirals bind directly to viral DNA polymerase?
Foscarnet
Famciclovir is rapidly phosphorylated by viral thymidine kinase to give what?
Penciclovir monophosphate
Which virus were two patients treated with high doses of ribavirin cured (disease is normally non curable)?
SSPE (Measles complication)
What is the only FDA approved monoclonal antibody for RSV virus?
Palivizumab
What does Palivizumab target?
Fusion protein
What step do neurominidase inhibitors target?
Viral release
What is the most potent oral antiviral drug for chronic hepatitis B?
Entecavir
What two drugs are in Truvada?
Truvada®, a combination of EMTRIVA® (emtricitabine) and VIREAD® (tenofovir disoproxil fumarate)
What is the landmark drug given for pre-exposure prophylaxis for HIV?
Truvada
What is the MOA of Acyclovir and Cidofovir?
Gets phosphorylated to the active form of the drug that gets incorporated into the growing DNA chain and won’t allow addition of fresh nucleotides.
